Otto, Lukas
1). Based on this observation, one possible explanation for the widespread use of interaction domains is that they allow for the rapid evolution of new signaling pathways, by the incorporation of a novel interaction domain into a pre-existing polypeptide. For example, yeast have no functional SH...
the proportion of amino acid repeats exponentially decreases as the number of repeat units increase in all types of AAR (Fig.4). This suggests that there could be functional adverse effects when an AAR becomes too large. To characterize the potential biological effects of the size variation of ...
Within biological systems, several activities involving the basic units of a gene take place. Such processes as DNA replication, and RNA translation and transcription into proteins must be controlled; otherwise, the systems could yield numerous destructive or useless gene products. Transcriptional control...
The recently updated classification of CRISPR-Cas systems divides them into three distinct types (I, II and III) [20]. All these systems contain two universal genes:cas1, a metal-dependent DNAse with no sequence specificity that could be involved in the integration of the alien DNA (spacer)...
(P ≤ 0.01). Its explanation is illustrated in Fig.1, showing the cultivars in admixed group within cluster 5 share some common alleles with the Hungarian and Monor groups. These latter two groups are isolated from each other, which is indicated by their strong bootstrap support and ...
The recently updated classification of CRISPR-Cas systems divides them into three distinct types (I, II and III) [20]. All these systems contain two universal genes:cas1, a metal-dependent DNAse with no sequence specificity that could be involved in the integration of the alien DNA (spacer)...
See their discussion for an explanation of the lack of robustness to skewness of standard tests when individual group means or medians are used instead of the global ones. Conover et al. (2018) also considered the lognormal distribution, which corresponds to the g-and-h distribution with g=...
Lastly, we see the limiting distributions in panel (c), which confirm the explanation given above; for large mutation rates, the population is balanced between the fittest trait 00, and its opposite 11. Figure 2. For the given fitness function (a), we see that mutation is eventually ...
not delivering convincing evidence for the existence of underlying latent factors. However, these parameters have been described as particularly difficult to estimate and their estimation appears to require a very large number of trials [40]. Thus, a probable explanation for this result is the insuff...