Understanding polymorphism in pharmaceutical ingredients is a long-standing challenge in formulation science. A well-known example is paracetamol, C8H9NO2. The marketed stable form I crystallizes with corrugated
Few genetic markers, if any, have found such widespread use as microsatellites, or simple/short tandem repeats. Features such as hypervariability and ubiquitous occurrence explain their usefulness, but these features also pose several questions. For example, why are microsatellites so abundant, why ar...
For understanding long-range interactions within the genome of a given individual haplotypes of 1 Mb or greater could be desirable, for example for resolving HLA (or BoLA) haplotypes. However for understanding the haplotype structure of populations, to increase the power of mapping studies, then ...
Polymorphism is used when you have different derived classes with the same method, which has different implementations in each class. This behavior is achieved through virtual methods that are overridden in the derived classes. In some situations there is no meaningful need for the virtual method to...
In many models of neurodegeneration, increasing the activity of protein degradation pathways can reduce neurodegeneration [236,251]. For example, inDrosophiladeficiency of S5b/PSMD5, the 26S proteasome regulatory subunit increases proteasome activity and reduces Tau rough eye phenotype [271]. Another ...
Polymorphism (and why it's bad) spring-data-mongodbsupports polymorphism via a rather questionable mechanism: when the nested bean's type is not deductable from the java generic type, it would simply place an_classfield in the document to specify the fully qualified class name for deserializatio...
Fig-associated wasps: pollinators and parasites, sex-ratio adjustment and male polymorphism, population structure and its consequences. In: Choe J, Crespi BJ, editors. The evolution of mating systems in insects and arachnids. Cambridge: Cambridge University Press; 1997. p. 226–39. Chapter Google...
Example of integration of supplier model with address polymorphism. <?phpnamespaceApp\Supplier;useFndmiranda\SimpleAddress\Entities\Address;useIlluminate\Database\Eloquent\Model;useFndmiranda\SimpleAddress\Pivot\AddressPivot;classSupplierextendsModel {/*** The attributes that are mass assignable.** @var ...
One example is a polymorphism that affects expression of the D178N mutation in the prion protein gene (PRNP), which causes familial Creutzfeldt-Jakob (fCJD) disease in some individuals and fatal familial insomnia (FFI) in others (Harder et al. 1999). The phenotypic differences among ...
For example, sequences from lectotype material of Gelidiella tenuissima Feldmann & Hamel (type locality: Biarritz, France) enabled the identification of specimens from Gran Canaria7. Grusz & Freshwater13 analyzed sequences from the isotype of Gelidium sclerophyllum W.R.Taylor (type locality: ...