Fundamental problems faced by the protocells and their modern descendants include how to go from one phenotypic state to another; escape from a basin of attraction in the space of phenotypes; reconcile conflicting growth and survival strategies (and ther
A major challenge for modern molecular biology consists in deciphering the complex regulation of gene expression. During the two last decades, numerous experimental and computational approaches have been developed to identify functional regulatory domains in genes. Binding sites for transcription factors (TF...
Hybrid models are often multiscale by definition integrating processes on different temporal and spatial scales, such as gene expression, intracellular pathways, intercellular signaling, cell growth, or migration. There are two general classes of hybrid models, those that are defined upon a lattice ...
Alistair RR Forrest4,8, the FANTOM consortium and Lukasz Huminiecki2,3,5,6,7* Abstract Background: Conventional wisdom holds that, owing to the dominance of features such as chromatin level control, the expression of a gene cannot be readily predicted from knowledge of promoter architecture. ...
This definition of the initial phase space of the beam has essentially no impact on the simulated field shape at the irradiation position. The field shape is almost entirely (> 99%) determined by the multiple scattering in the 1.16 mm Pb scatter foil, mounted 100 mm downstream from the ...
1. “Simple Squamous Epithelium – Definition and Examples.” Biology Dictionary. 2. “Stratified Squamous Epithelium – An Overview.” ScienceDirect. Image Courtesy: 1. “Simple squamous epithelium” By Kamil Danak – Own work(CC BY-SA 3.0)via Commons Wikimedia ...
Nowhere is a definition of ‘molecular complementarity’ given in the text: there are many types of non-covalent interactions that hold things together in biological systems. A strategy of grouping all of them under the same term does not seem very helpful. ...
Examples and applications of in silico modeling for some important categories of diseases (such as for cancers, infectious diseases, and neuronal diseases) are also given. What You Can Expect to Know Recent advances in bioinformatics and systems biology have enabled modeling and simulation of sub-...