The cytoskeleton is a key element in the organisation of eukaryotic cells. It has been described in the literature that the properties of actin are modulated by small heat-shock proteins including a direct actin-small heat-shock protein interaction to inhibit actin polymerization to protect the ...
The N-terminal part of CYLD comprises three cytoskeleton-associated protein- glycine-rich (CAP-Gly) domains (Figure 1), the first two mediating microtubule binding, whereas the third CAP-Gly domain binds to the inhibitor of κB (IκB) kinase (IKK) adaptor protein NEMO.6,7 CYLD further ...
Stable radiation and drug resistance was associated with coordinate changes in the expression of genes of the cytoskeleton, protein synthesis, cell cycle, redox/stress and metabolic pathways. The pattern of these changes was remarkably similar to the changes seen 24 h after a single X-ray ...
The presence of SA in drinking water led to S-nitrosylation of key proteins in the striatum region. Some of these proteins were found to be associated with the pathology of AD, PD, and ASD. Thus, microtubule-associated protein 1B (MAP-1B), which is responsible for cytoskeleton stabilization...
G protein-coupled receptor; MTT, 3-(4,5-dimethyl-2-thiazolyl)-,5-diphenyl-2H-tetrazolium bromide; VBL, vinblastine; Tyr, tyrosine; NES, nuclear export signal; cytoD, cytochalasin D; ROCK, Rho-associated kinase; CHOP, Chinese hamster ovary cells expressing polyoma LT antigen; CHAPS, 3-[(...
betweenmembraneproteinsandcytoskeletonunderlies thediffusion impedance. The impedance was also ob- served both for Thy-1, linked only to lipids in the outer membrane leaflet, and for other membrane glycopro- teins that bind the lectin ConA. Therefore, the sheer density of membrane proteins re...
Among the most enriched GO-terms related to cardiomyocytes were heart development, blood vessel and muscle tissue development, myofibril assembly, muscle contraction, ECM structural constituent, calcium ion binding, actin binding, contractile fiber, myofibril, sarcomere, actin cytoskeleton, collagen, Z ...
ementofthecytoskeleton(forreviews,see[1,2]).During embryogenesis,theexpressionoftheindividualsubunitsof themultigeneproteinfamilyfollowsstrictdi¡erentiation directives,culminatinginthecelltype-speci¢cdeposition ofthedi¡erentIFproteinsintheterminallydi¡erentiated tissuesofthematureorganism(forareview,see...
This phenomenon results from changes in gene expression, cellular interactions, cytoskeleton structure, signal transduction, and disturbed expression of cell cycle regulatory proteins (reviewed in [13,14]). As to humoral immunity, it was shown using the urodele amphibian Pleurodeles waltl as animal ...
2-5μm per second. Thus, this is the key difference between slow and fast axonal transport. Moreover, slow axonal transports carry cytoskeleton polymers and protein complexes, while fast axonal transports carry mitochondria, membrane-associated receptors, neurotransmitters proteins, and synaptic vesicles...