Takeshita H, Moriyama S, Arai Y, Washino S, Saito K, Chiba K, Horiuchi S and Noro A: Randomized crossover comparison of the short-term efficacy and safety of single half-dose silodosin and tamsulosin hydro
Treatment of male rats with silodosin for 15 days resulted in decreased fertility at the high dose of 20 mg/kg/day (about 2 times the exposure at the MRHD based on AUC) which was reversible following a two-week recovery period. No effect was observed at 6 mg/kg/day. The clinical rele...