With regard to the therapeutic role of systematic lymphadenectomy, few data in literature are available and, most important, are not derived from experimental studies. Probably, only randomized studies with a large number of patients will provide useful answers....
Her mother kept a watchful eye while the preschooler stood at the end of the driveway for several moments. The child’s sister—eight years her senior—decided to go out and gently inquire about her younger sibling’s plans, to which Melissa responded ruefully, “I can’t run away. I ...
In summary, IDH1 is a sufficient marker that allows a better separation of primary GBM from other malignant astrocytomas than any other marker and will help to define more accurately this tumor entity in upcoming studies. The low number of primary GBM exhibiting IDH1 mutations in our series ...
as already observed,it is the motivated choice that concerns stylistics as an intermediary discipline.This discipline,which typically studies the relation between linguistic form and literary significance,has on the one hand a large number of practitioners and on the other no...
Prognostic significance of the location of intramural metasta- sis in patients with esophageal cancer. Langen- becks Arch Surg 2004;389(2):122-127.Yuasa N, Miyake H, Yamada T, Oda K, Nimura Y, Nagasaka T, Hattori T: Prognostic significance of the location of intramural metastasis in ...
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic cell death pathway in 2012, ferropt
The circadian clock is a transcriptional-translational feedback loop which oscillates in virtually all nucleated cells of the body. In the decades since its discovery, it has become evident that the molecular clockwork is inextricably linked to energy me
A well-balanced ion channel trafficking machinery is paramount for the normal electromechanical function of the heart. Ion channel variants and many drugs can alter the cardiac action potential and lead to arrhythmias by interfering with mechanisms like
The measurement of a particular liquid's change in viscosity when exposed to temperature changes is its viscosity index. A low viscosity index number indicates a liquid that will become more viscous with decreased temperature. A high viscosity index number indicates a liquid that will stay near ...
of vascular smooth muscle cells (VSMCs) via the PTEN pathway, thereby accelerating atherosclerosis [7]. Similarly, Yin Hu et al. demonstrated that exosomes containing miR-21-3p enhance fibroblast activation and angiogenesis in skin wound healing [8]. Additionally, a considerable number of circRNAs...