becomes advantageous when a small number of rules create a very large number of reactions, e.g., polymerization, aggregation, or multi-site phosphorylation55. However, such network-free simulators typically require an explicit representation of every molecule in the system, which dramatically increases...
We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The proximal BCR-ABL1 signaling network shows a modular and layered ...
Figure 2. A Systems-Level Signal-Response Dataset following Cisplatin (A) An expanded DNA damage signaling-response network, including canonical components of the DDR, growth, and stress response pathways. Signals integrated in the model are green, and responses are blue. (B) Protein abundance and...
Similarly, specific feedbacks in the DNA damage network are responsible for the differential dynamics of p53 in response to γ-irradiation and UV (Batchelor et al., 2011). In both networks, PI3 kinase-related kinases (ATM or ATR) relay the damage signal to p53, activating two core negative-...
Availability of AD pathway map in standardized formats (SBML and SBGN) renders the network applicable to systems-biology analyses based on various SBML compliant tools. Therefore, our AD pathway map will be an indispensable basic resource for both clarification of the pathogenic mechanism of AD and...
Loop-start signaling is a supervisory signaling technique that provides a way to indicate on-hook and off-hook conditions in a voice network. Loop-start signaling is used primarily when the telephone set is connected to a switch. This signaling technique can be used in any of these connections...
Focuses on the role of Distributed Open Signaling Architecture (DOSA) in the integration of call signaling and resource management for Internet protocol telephony. Requirements for first-line telephony performance; Guidelines on the tol... P Goyal,AG Greenberg,CR Kalmanek,... - 《IEEE Network》 ...
(E) The STRING outcomes were uploaded to Cytoscape software to identify hub genes using MCODE algorithm in the PPI network. (F) Venn diagram revealed that LTBP2 was the only BCR-associated hub gene. LTBP2, latent transforming growth factor β-binding protein 2; DEG, differentially expressed ...
all of the data presented here suggested that soybean responses to water stress could be regulated by a crosstalk network among different signaling pathways, which might involve various phytohormones, such as auxins, ABA and jasmonic acid. The integration ofin silicoand physiological data could also ...
circumcarinatum. We interpret some of these joint actions as signatures for a homologous genetic network that dates back (at least) to an ancestor of Zygnematophyceae and land plants. The symbiotic association with fungi was one of the key innovations that allowed plants to colonize land70. ...