The widely used sigmoid Emax model, which accounts for response saturation, relies heavily on the effective drug concentration ( E D 50 E{D}_{50} ). This reliance can lead to validation errors and inaccuracies in model fitting. The Emax model cannot generate multiple DRCs, raising concerns ...
Is it possible to estimate the parameters of the sigmoid Emax model with trucated data typical of clinical studies. J Pharm Sci. 1996; 85 :232–239. [ PubMed ]Dutta S., Matsumoto Y., Ebling W.F. (1996). Is it possible to estimate the parameters of the sigmoid E max model with ...
Alvan G, Hammarlund-Udenaes M, Odlind B. The va- lidity of the sigmoid Emax model and efficiency concept in diuretic studies. Br J Clin Pharmacol 1991; 31:210.Alván, G. , Hammarlund-Udenaes, M. & Odlind, B. ( 1991 ). The validity of the sigmoid E max model and efficiency ...
We investigated the relationship between the steepness of the concentration-effect relationship and inter-individual variability (IIV) of the parameters of the sigmoid Emax model, using the similarity between the sigmoid Emax model and the cumulative log-normal distribution. In addition, it is ...