The fruit fly Drosophila melanogaster has proven to be a powerful model organism to study how HRE causes ALS and FTD neuropathologies51. Expression of expanded (G4C2)-RNA repeats in Drosophila leads to retinal degeneration, functional deterioration of motor neurons and locomotor defects52,53,54...
4. Su, T.P., London, E.D. & Jaffe, J.H. Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science 240, 219-21 (1988). 5. Monnet, F.P. & Maurice, T. The sigma1 protein as a target for the non-genomic effects of neuro(active)...
Sigma-1R KD (μM) Sigma-2R KD (μM) Sigma2/ C R1 R2 Ligand (±SEM, n = 3), R2 (±SEM, n = 3), R2 Signal H— H— H3C— H— H3C— H3C— Tryptamine N-methyltryptamine N,N′-dimethyl-tryptamine 0.011 0.085 1.472 H— H— H3C— H— H3C— H3C— Phenethylamine (PEA) N-me...
the figure. No change in the expression of GRP78/BiP or GRP94 as a result of Flv treatment was observed. (d) Flv (10 μg/ml) was added to Neuro2a cells, and the expression of total eIF2αand phosphorylated eIF2αwas measured over the time course shown in the figure. No change ...