Anti-sigma factors bind to sigma factors and inhibit their transcriptional activity. Studies on the mechanism of action of anti-sigma factors has shed new light on the regulation of gene expression in bacteria, as the anti-sigma factors add another layer to transcriptional control via negative ...
The sigma factors in Gram-positive and Gram-negative bacteria are called σS (RpoS) and σB (SigB), respectively (Boor, 2006). Both RpoS and SigB belong to the σ70 family sigma factors, which are mainly related to bacterial stress response. The role of sigma factors is to bind to ...
These specializedsigma factorsbind the promoters of genes appropriate to the environmental conditions, increasing the transcription of those genes. WikiMatrix It is involved in ensuring thesigma factorwill only bind the promoter when it is complexed with the RNA polymerase. ...
Biochem/physiol Actions Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes. A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression,...
Question: During transcription initiation in eukaryotes,sigma factor recognizes and binds a promoterthe general transcription factors and RNA polymerase bind to the promoter to form the transcription initiation complexRNA polymerase adds ribonucleotides to the 3' ...
(ECF) sigma factors that regulate bacterial responses to diverse stresses12. As yet, no molecular mechanism has been described for the stress-induced inactivation of any ZAS protein. We detail the mechanism by which RsrA responds to oxidation, releasing σRto mount the cellular anti-oxidant ...
influenced in turn by such factors as the host intracellular environment, low pH, iron limitation, and nutrient limitation concurrent with reaching the stationary growth phase. The gene products ofspvABCDappear to enhance intracellular multiplication and systemic dissemination. Minor sequence differences ins...
STRUCTURE AND FUNCTION OF BACTERIAL SIGMA FACTORS In the eubacteria, transcription initiation requires specificity proteins, known as σ factors, that bind reversibly to the catalytically active core RNA p... JD Helmann - 《Annual Review of Biochemistry》 被引量: 1860发表: 1988年 Genome Sequence ...
RsrA is a zinc-binding anti-sigma factor (ZAS) protein, the prototypical member of a large family of inhibitors of extracytoplasmic function (ECF) sigma factors that regulate bacterial responses to diverse stresses12. As yet, no molecular mechanism has been described for the stress-induced ...
22. Sigma factors are thought to have transferred from the plastid genome to the nuclear genome during the evolutionary history of plants, thus providing a mechanism for nuclear control of plastid transcription20,21. TheArabidopsis thaliana(Arabidopsis) nuclear genome encodes six sigma factors (SIGMA ...