缺血后神经元不能维持正常的跨膜离子梯度和动态平衡,即触发病理过程,如兴奋性毒性反应、内质网应激(endoplasmic reticulum stress, ERS)、线粒体功能障碍和炎症因子释放等,从而导致缺血性神经元死亡和血脑屏障(blood‑brain barrier, BBB)损伤[2]。 通过在时间窗口内进行早期再灌注挽救缺血半暗
Sigma(σ)是希腊字母之一,中文音译为“西格玛”,其含义需结合具体领域分析。在数学、统计学及管理学中,该符号具有不同的应用场景,既可作为数学运算符,也可用于衡量数据离散程度或代表质量管理体系。以下从基本定义、核心应用及跨领域扩展三个维度展开说明。 一、基本定义:音译与符号来源 Si...
Sigma 1 receptorOxidative stressER stressHumanLensCataractStimulation of sigma-1 receptors is reported to protect against oxidative stress. The present study uses cells and tissue from the human lens to elucidate the relationship between the sigma 1 receptor, ER stress and oxidative stress-induced ...
It has been suggested that sigma receptors are involved in anxiety since Lu 28-179, a sigma2-receptor agonist, has anxiolytic properties in rodents. In addition to the depressive animal model, phenytoin-sensitive sigma1-receptor agonists such as (+)-SKF-10,047 and dextromethorphan attenuate the ...
Doxorubicin (DOX) is an anthracycline with potent antitumor properties and rare yet serious cardiotoxic side effects that limit its clinical application. The sigma-1 receptor is a stress-triggered chaperone often dysregulated in diseases and has known ca
The 68-95-99.7 rule tells us that 68% of the population is between -1 and +1 sigma from the average; 95% is between -2 and +2 sigma from the average; and 99.7% is between -3 and +3 sigma from the average. For the example of IQ, 68% of the population has an IQ between 85...
2.1.1Sigma 1 receptor Dr T. Maurice’s group and its collaborators have worked intensively on the effects of steroids that involve Sigma 1 receptor activation. This receptor has been cloned in several species and is widely expressed both in the brain (in neurons and oligodendrocytes) and the ...
sigma‑1受体(sigma‑1 receptor, Sig‑1R)广泛分布于中枢神经系统,参与多种神经和精神疾病的病理生理变化,如阿尔茨海默病、帕金森病、脑卒中、神经性疼痛、精神分裂和抑郁症等[3]。多项体内外研究表明,Sig‑1R配体在广泛的时间窗口内表现出独特...
Sigma-1 receptor chaperones rescue nucleocytoplasmic transport deficit seen in cellular and Drosophila ALS/FTD models Pin-Tse Lee, Jean-Charles Liévens, Shao-Ming Wang, Jian-Ying Chuang, Bilal Khalil, Hsiang-en Wu, Wen-Chang Chang, Tangui Maurice & Tsung-Ping Su Nature Communicatio...
We recently demonstrated that endoplasmic reticulum (ER) stress induces sigma-1 receptor (Sig-1R) expression through the PERK pathway, which is one of the cell’s responses to ER stress. In addition, it has been demonstrated that induction of Sig-1R can