The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding pocket and acts to influence cellular activities similar to the sigma-1 receptor. Both proteins are highly expressed ...
Sigma-1 receptors are unique therapeutic targets modulating the activity of various proteins and systems in the organism. • Preclinical studies reported that sigma-1 receptor expression correlates with the clinical manifestation of disease. • Animal studies suggest that targeting sigma-1 receptors mi...
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at con...
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell 2007; 131: 596–610. 7. Al-Saif A, Al-Mohanna F, Bohlega S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann Neurol 2011; 70: 913–919. 8....
Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer. J Exp Clin Cancer Res. 2012;31:41.Hornick, J. R.; Vangveravong, S.; Spitzer, D.; Abate, C.; Berardi, F.; Goedegebuure, P.; Mach, R. H.; Hawkins, W. G....
1.Cesen MH, et al. Cell Death Dis. 2013 Oct 3;4:e818. 关键词 σ2Siramesine HydrochlorideSiramesine hydrochlorideSiramesineSigmareceptorSigma receptorSigma Receptorselectivitymitochondrialysosomeslysosome-destabilizing agentlysosomalautophagylysosomal autophagyLu 28-179 HydrochlorideLu 28-179InhibitorinhibitFe...
≥98% (TLC), powder, D2 dopamine receptor antagonist 同義詞: 2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐, CPZ, 氯普马嗪 登入查看組織和合約定價About This Item 經驗公式(希爾表示法): C17H19ClN2S· HCl CAS號碼: 69-09-0 分子量:: 355.33 Beilstein: 3779989 EC號碼: 200-701-3 MDL號碼: MFC...
Post receptor stimulation, most notably by TNFα, NIK, a serine/threonine kinase, activates and phosphorylates IKKα and IKKβ. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates, which ...
Previous studies have shown that siramesine, a sigma-2 receptor agonist originally developed as an anti-depressant, can induce cell death in transformed cells through a mechanism involving lysosomal destabilization. Since MCs are remarkably rich in lysosome-like secretory granules we reasoned that MCs...
3.3.2. Differentially Abundant Proteins in HIV-1-Infected MDM after Exposure to Cocaine HIV-1-infected MDM exposed to cocaine, in comparison to HIV alone, revealed seven upregulated proteins in HIV-1-infected MDM (Table 2). These include the proteasome 26S subunit ubiquitin receptor, non-ATPas...