and Siglec-15 also exhibits PD-L1-like related effects, which suggests that it may be a novel immune checkpoint. Siglec-7 and Siglec-9 are highly expressed in NK cells, and these Siglecs exhibit immunosuppressive effects ...
Recent studies have suggested that sialic acid- binding immunoglobulin-type lectin (Siglec) family members are abundantly expressed in innate immune cells, such as macrophages, natural killer (NK) cells and dendritic cells (DC), and are shown to be related to the development of tumors. Different...
Upon binding of these ligand glycans, Siglec-7-expressing immune cells showed reduced cytotoxic activity, whereas cancer cells expressing ligand glycans underwent signal activation, leading to enhanced invasion activity. To clarify the structure of the ligand glycan, podoplanin (PDPN) identified as a ...
英文摘要 Bone marrow–derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to ...
(green, canonical arginine residue; red, noncanonical arginine residue; orange, cysteine residues involved in the interdomain disulfide bridge, non-arginine residues; yellow).dandenGLLs formulated with5binding to CHO cells expressing Siglec-6 mutants (n = 4 technical replicates). Liposome ...
The effect was reflected in all known Siglec-E-expressing cells, especially macrophages (Figures 6J and S7C). These results indicate that CD24 directly modulates the Siglec-E-SHP-1 signaling to dampen inflammatory response. The key inhibitory role of the CD24-Siglec-E axis in metabolic ...
Siglec1 is expressed in many types of immune cells with a preferential expression in macrophages [27]. In contrast, IFNAR is extensively expressed in many tissues and cell types, and highly expressed in immune cells. As innate immune cells, especially macrophages and DCs, are important IFN-...
Inhibiting them can enhance the functions of several types of immune cells, whereas engaging them can reduce hyper-inflammation and hyper-activation of immune functions. Siglec-sialoglycan interactions play an important role in modulating immunological functions during cancer, however, their roles in ...
Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that...
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are known to promote cell-cell interactions and regulation of innate and adaptive immune function via glycan recognition1. The CD33-related (CD33r) subgroup of siglecs is mainly expressed on human immune cells like monocytes, macrophages, and...