The overall prevalence of inflammatory side effects did not differ across therapies. In a subanalysis, patients treated with both single-agent and combination therapies were more likely to experience an inflammatory side effect on single-agent therapy (P=0.0126 for BRAF inhibitor, P=0.0833 for MEK...
Unresectable or Metastatic Melanoma with BRAF V600E Mutation This section describes adverse drug reactions (ADRs) identified from analyses of Trial 1 and Trial 2 [seeClinical Studies]. Trial 1 randomized (1:1) 675 treatment-naive patients with unresectable or metastatic melanoma to receive ZELBORAF ...
Rajni Kannan, BS, MS, RN, ANP-BC, Nurse Practitioner, NYU Cancer Institute, NYU Langone Medical Center, discusses the importance of educating patients with metastatic melanoma on the side effects associated with the immunotherapy ipilimumab (Yervoy) and the BRAF inhibitor vemurafenib (Zelboraf)....
Zelboraf is used to treat melanoma (skin cancer) that has spread to other parts of the body or cannot be removed by surgery.Zelboraf is also used to treat Erdheim-Chester Disease (a rare blood cancer).Zelboraf is used only if your cancer has a specific genetic marker (an abnormal "BRAF"...
eliminate the rash, researchers looked to BRAF inhibitors, a relatively new cancer therapy used to treat melanoma. In the laboratory, UCLA researchers discovered that BRAF inhibitors could also be used to help speed up how the skin repairs itself from injury and lessen skin-related side effects....
Common side effects of Dabrafenib include: Headache, Muscle or joint pain, Bleeding, Fever, Chills, Tiredness, Dry skin, Thickened skin, Warts, Rash, Swelling in the legs, arms, and face, Redness, swelling, peeling, or tenderness of hands or feet, ...
Carlos G, Anforth R, Clements A, Menzies AM, Carlino MS, Chou S, et al. Cutaneous toxic effects of BRAF inhibitors alone and in combination with MEK inhibitors for metastatic melanoma. JAMA Dermatol. 2015;151(10):1103–9. PubMedGoogle Scholar ...
Drug Class:Antineoplastics, BRAF Kinase Inhibitor Dabrafenib is an anticancer (antineoplastic) medication used in the treatment of certain types ofmelanomaskin cancer, lung and thyroidcancers, and solid tumors. Dabrafenib is used as monotherapy or in combination with trametinib, another antineoplastic dru...
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and NailsTargeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common ... M Lacouture,V Sibaud - 《American Journal of Clinical...
Tecentriq is used to treat adults with a type of skin cancer called melanoma.It may be used with the medicines cobimetinib and vemurafenib when your melanoma has spread to other parts of the body or cannot be removed by surgery, and has a certain type of abnormal “BRAF” gene. Your ...