Bosentan has been given as a single dose of up to 2400 mg in normal volunteers, or up to 2000 mg/day for 2 months in patients, without any major clinical consequences. The most common side effect was headache of mild to moderate intensity. In the cyclosporine A interaction study, in whic...
cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam, olanzapine, oral and other hormonal contraceptives, oxcarbazepine paliperi...
Levofloxacin Cmax and ke were slightly lower while Tmax and t1/2 were slightly longer in the presence of cyclosporine than those observed in other studies without concomitant medication. The differences, however, are not considered to be clinically significant. Therefore, no dosage adjustment is ...
Some commonly experienced side effects include [25, 20]: Abdominal cramping Bloating Diarrhea Flatulence Gas Nausea Weight loss Drugs Interactions The following listed drug interactions are not exhaustive. Please speak to your doctor if you are taking medication. Grape juice may inhibit cyclosporine, ...
EMEND should be used with caution in patients receiving concomitant orally administered active substances that are metabolised primarily through CYP3A4 and with a narrow therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, ergot alkaloid derivatives, fentanyl, and quinidin...
Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs. Use of celecoxib may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics,ACE inhibitors, orangiotensinreceptor blockers [ARBs]) [seeDRUG INTERACT...
Cell lines/ Model Activity/mechanisms of action Application References Acute toxicity Subacute toxicity Cytotoxicity ICR mice Rabbits Dogs MT-2 cells L-02 cells LD50 = 315.80 mg/kg (p.o.) and 40.28 mg/kg (i.m.) 0.08 mg/kg (i.m.): no substantial lesion; 1.2 mg/kg (i...
This product should be used with caution in patients receiving concomitant orally administered active substances that are metabolised primarily through CYP3A4 and with a narrow therapeutic range, such as cyclosporine, tacrolimus, sirolimus, everolimus, alfentanil, diergotamine, ergotamine, fentanyl, and ...
Jarowenko MV, Van Buren CT, Kramer WG, Lorber MI, Flechner SM, et al. Ranitidine, cimetidine and the cyclosporinetreated recipient. Transplantation 42: 311–312, 1986. PubMedCASGoogle Scholar Jensen JC, Gugler R. Relevant inhibition of acetylcholinesterase with H2-receptor antagonists. Zeitschrift...
Jarowenko MV, Van Buren CT, Kramer WG, Lorber MI, Flechner SM, et al. Ranitidine, cimetidine and the cyclosporinetreated recipient. Transplantation 42: 311–312, 1986. PubMedCASGoogle Scholar Jensen JC, Gugler R. Relevant inhibition of acetylcholinesterase with H2-receptor antagonists. Zeitschrift...