The fetal effects of maternal finasteride exposure during the period of embryonic and fetal development were evaluated in the rhesus monkey (gestation days 20-100), in a species and development period more predictive of specific effects in humans than the studies in rats and rabbits. Intravenous ad...
or has effects on the breastfed infant. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for FOSAMAX and any potential adverse effects on the breastfed child from FOSAMAX or from the underlying maternal condition. ...
The fetal effects of maternal finasteride exposure during the period of embryonic and fetal development were evaluated in the rhesus monkey (gestation days 20-100), in a species and development period more predictive of specific effects in humans than the studies in rats and rabbits. Intravenous ad...
Reports on a study by scientists in Canada showing the potential risk of exposure of swimmers in indoor pools to chloroform, a possible cancer-causing agent for humans. Susceptibility of competitive swimmers to experience elevated levels of chloroform in the blood; Absorption of the chemical into ...
(the addition of salt can separate PA from water, which can be used for acid separation/purification), and it also dissolves in ether, ethanol or chloroform. PA reacts with alcohols and bases to form esters and organic salts. The concentrated form of PA irritates the skin and mucous ...
Because of the known effects of non-steroidal anti-inflammatory drugs on the fetal cardiovascular system (closure of ductus arteriosus), use during pregnancy (particularly during the third trimester) should be avoided. Labor And Delivery In rat studies with NSAIDs, as with other drugs known to ...
This conclusion argues against the use of GlyT2 inhibitors for enhancing glycinergic control due to side effects such as muscular disorder, as seen in GlyT2-deleted mice and humans with mutations within the GlyT2-encoding gene. However, this conclusion may not be clinically applicable because ...
Total mRNA from aortic and brain tissue was isolated using the acid guanidinium thiocyanate–phenol–chloroform extraction method. 125 ng of total RNA was used for quantitative reverse transcription real-time PCR (qRT-PCR) analysis using QuantiTect Probe RT-PCR kit (Qiagen) as described previously ...
There are limitations in our study. Firstly, only the mouse models were used to test the therapeutic effects of PLT3. Due to the differences in anatomical locations and functions of adipose tissues between mice and humans, the translational potential of PLT3 needs to be further evaluated in lar...
high-dose male rats (p=0.003) in a 2-year oral carcinogenicity study at doses of 1 and 3.75 mg/kg body weight. These doses are equivalent to approximately 0.3 and 1 times the 40 mg clinical daily dose based on surface area, mg/m2. The relevance of this finding to humans is ...