Sickle cell crisis, a hallmark of sickle cell anemia, arises from the unique pathophysiology of this inherited hemoglobinopathy. The condition, characterized by a point mutation in the beta chain of the globin gene, leads to the synthesis of abnormal HbS protein, causing various crises. Vaso-occlu...
Methods: A retrospective cohort analysis was conducted utilizing International Classification of Diseases (ICD-10) codes to identify adults who were admitted with a principal diagnosis of sickle cell crisis. The primary outcomes examined were inpatient mortality, while the second...
To the Editor: Bone pain with fever is a frequent presentation for children with sickle cell disease (SCD). Clinical, laboratory, and radiographic features of vaso-occlusive crisis (VOC), bone infarction, and osteomyelitis frequently overlap. All can present with fever, localized or multifocal ...
The acute chest syndrome in sickle cell disease: incidence and risk factors. Blood. 1994;84(2):643-649.PubMedGoogle Scholar 10. Eisenbrown K, Nimmer M, Ellison AM, Simpson P, Brousseau DC. Which febrile children with sickle cell disease need a chest X-ray? Acad Emerg Med. 2016;23...
this study includes a very large sample size and utilized ICD-10, allowing us to include only those patients who were diagnosed with SCC on discharge. There is no information on the severity of sickle cell crisis or on therapeutic regimens in NRD therefore their impact on readmission could not...
SCD patients are at significantly higher risk for systemic complications including acute chest syndrome, pain crisis, splenic sequestration crisis, acute renal failure, higher need for blood transfusions and deep venous thrombosis during the initial peri-operative period following TKA....
However, little is known about the prevalence, variety and severity of thrombus particularly in sickle cell patients hospitalized with vaso-occlusive crisis. Methods We made a retrospective chart review of patients (age 21 years or older) admitted with sickle cell disease at Hurley Medical Center (...
The arrhythmia group consisted mostly of patients' sickle cell disease (5,650; 95%), while 245 had sickle cell trait, and 35 were classified as having other sickle cell disorders. Individuals in the arrhythmia group were significantly older (mean age 41.3, SD 14.1) than those with no ...
METHODS: This observational cohort study included all adult sickle cell patient visits (1 June 2004-31 May 2005) to two ED. Patients were identified by ICD-9 codes of vaso-occlusive crisis and lists from treating haematologists. ED charts wereed for history, physical examination, laboratory/...
Results: There were 884 ED visits by 125 patients (mean age 36 years/55% female/58% homozygous sickle cell disease). 199 ED visits had one or more outcome (197 transfusion/antibiotic treatment, 71 acute chest syndrome, and one aplastic crisis). The risk score included sickle variant, chest...