Sickle Cell Disease (Clinical) Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous...
An aetiological workup was done to rule out infective endocarditis, tuberculosis, diabetes, and other immunocompromised conditions. Haemoglobulin electrophoresis showed sickle cell trait. Twenty months later, the patient is currently completely asymptomatic.Although a rare entity, fungal splenic abscess ...
This report aims to highlight the importance of careful diagnostic workup in patients with sickle cell trait presenting with hematuria. A 49-year-old African–American male with sickle cell trait presented with a history of intermittent, sharp left flank ... 展开 ...
[5] arising from a wide variety of insults to the liver in patients with SCD; it is a relatively uncommon complication that occurs predominantly in patients with homozygous sickle cell anemia and to a lesser extent in patients with sickle cell trait, hemoglobin SC disease, and hemoglobin S β...
This cohort study evaluates whether African American individuals with sickle cell trait have a higher incidence of myocardial infarction or composite
Slightly decreased Hb A; Moderate amount Hb S (about 40%)Sickle cell traitOne gene copy for Hb S (heterozygous) Majority Hb S; Increased Hb F (up to 10%); No Hb ASickle cell diseaseTwo gene copies for Hb S (homozygous) Is there anything else I should know?
cells in the distal portion of capillaries, and dilatation and thinning of the proximal segments of the vessels [321]. Visual acuity is not affected. The “comma sign” vessels in conjunctiva are an excellent diagnostic tool for sickle cell disease, but they are absent in sickle cell trait. ...
Imaging suggested autosplenectomy, and workup revealed a negative thrombophilia profile but was positive for sickle cell trait (SCT). Individuals with SCT can be asymptomatic until exposure to severe hypoxia, upon which they can manifest clinically as sickle cell syndrome. We discuss the rare ...
He was known to have sickle cell trait and was on iron on and off during periods of anemia. History was negative for weight loss, high or prolonged fever, night sweats, recurrent skin, or any other documented infections or any other form of blood loss. His mother aiso reported that he ...
Both her parents are consanguineous and have the sickle cell trait, whereas all her siblings are sickle cell-negative on the basis of routine screening. The patient had no history of hypertension, diabetes, or other conditions of medical concern; no history of previous surgeries; and no history...