Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous condition, is the only 1 of...
Sickle cell trait–positive women were older than the sickle cell trait–negative women (24.4± 4.6 vs 23.0± 4.4 years, p < 0.001 ), but there was no significant difference in parity. The rate of preeclampsia was significantly increased in sickle cell–positive women (24.7% vs 10.3%, p ...
Sickle cell disease is a serious haemolytic disorder caused by homozygosity for haemoglobin S. The sickle cell trait is its milder heterozygous counterpart in which there is both haemoglobin S and A. The gene is found in Africa and Mediterranean countries. Whenever oxygen tension drops, haemoglobin...
In Nigeria, it is estimated that 24% of the population have sickle cell trait [7], making it the country with the largest population of individuals with sickle cell trait worldwide [7]. According to Mulumba et al, about 150,000 Nigerian children are born with sickle cell disease annually ...
sickle cell disease and after infection byP. falciparum, especially in RBCs with sickle cell trait. The high mannose glycans can be recognized by the mannose receptor (CD206) expressed on macrophages and Lyve-1+ endothelial cells in the spleen to effect phagocytosis. High mannose glycans, ...
Patients with sickle cell disease (SCD) regularly experience abnormal sleep, characterized by frequent arousals and reduced total sleep time. However, obst
Sickle cell traitGlucose 6-phosphate dehydrogenaseCo-inheritanceFoetal haemoglobinPreviously published data have demonstrated that sickle red blood cells produce twice as much reactive oxygen species (ROS) suggesting that co-inheritance of sickle cell disease (SCD) and glucose 6-phosphate dehydrogenase (...
The aim of this study is to determine the feasibility of large-scale population screening for the sickle cell gene in high risk areas with limited resources. A programme designed to detect the sickle cell trait and sickle cell disease has screened 359,823 subjects among 2,087 (99.7%) of ...
Control participants included 5 with sickle cell trait (HbAS) and 11 normal (HbAA). There was no significant difference between the SCD and control groups in age, sex, and ethnicity (Table 1). The SCD group had significantly higher PASS scores, reflecting higher pain-related anxiety. The ...
Mobilized peripheral blood is increasingly used as the source of hematopoietic stem cells for allogeneic transplantation, currently the only curative approach for sickle cell anemia. However, the safety and feasibility of stem cell mobilization in individuals with sickle cell trait (SCT) has not been ...