Vaso-occlusive crisisAcute chest syndromeEmergency departmentAcute painful episodes are the most common reason for emergency department visits among patients with sickle cell disease (SCD). Early and aggressive pain management is a priority. Emergency providers (EPs) must also diagnose other emergent ...
PRIMER Sickle cell disease Gregory J. Kato1, Frédéric B. Piel2, Clarice D. Reid3, Marilyn H. Gaston4, Kwaku Ohene‑Frempong5, Lakshmanan Krishnamurti6, Wally R. Smith7, Julie A. Panepinto8, David J. Weatherall9, Fernando F. Costa10 and Elliott P. Vichin...
pathologies during the recent crisis, as well as asthmaandsickle-cellanaemia, for which an increase in doctor visits has also been registered. daccess-ods.un.org daccess-ods.un.org 在最近的危机期间,心理 健康疾病骤增,哮喘和镰状细胞贫血病也激增,因为 记录在案的看病人数增多。
Advances in pediatric sickle cell care Review between ages 5 mo and 2 y represent most cases of splenic sequestration (31). During severe sequestration crisis, the blood-filled spleen may enlarge to the point of filling the entire abdomen, the hemoglobin may drop acutely (at least 2 g/dl...
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Ha
The article shows that in areas without screening programs for newborns, the initial diagnosis of SCD occurs at approximately 21 months of age. For many individuals, the first sign of sickle cell anemia is a fatal infection or an acute splenic sequestration crisis, when sickledred blood cellsbeco...
orphan diseases such as sickle-cell disease. daccess-ods.un.org y 全民健康,尤其是努力防治肆虐非洲大陆的重大流行性疾病和祸患,例 如艾滋病毒/艾滋病、麻风病、肺结核、线虫病和孤 儿 病, 如 镰刀 型 红血 球疾病。 daccess-ods.un.org [...] respiratory diseases, hemoglobulinopathies, especia...
Once a fatal disease of childhood, more than 95% of patients born today with sickle cell disease (SCD) in developed countries are expected to survive into adulthood, largely because of improvements in supportive and preventive care (newborn screening, pe
To identify possible biomarkers for VOCs, the biomarkers panel conducted a PubMed query for “biomarker,”“pain,” and “sickle cell” including any articles in which potential biomarkers were assessed in human subjects with SCD during an acute pain crisis. Potential biomarkers assessed in patients...
Sickle cell disease (SCD) is an inherited red blood cell disorder caused by a structural abnormality of hemoglobin called sickle hemoglobin (HbS). Clinical manifestations of SCD are mainly characterized by chronic hemolysis and acute vaso-occlusive crisis, which are responsible for severe acute and ...