Sickle Cell Anemia Sickle cell is a homogenous genetic anemia caused when an abnormal gene (hemoglobin S or HbS) causes the substitution of the amino acid valine, for another, glutamic acid (Amundsen et al., 1984). The sickle gene protects heterogeneous carriers (HbC) from P. falciparum in ...
Pain. Frequent infections. A deep fatigue that’s hard to shake. These are a few of the challenges that can arise when you have sickle cell anemia (SCA), an inherited red blood cell disorder that’s part of a bigger group of disorders called sickle cell disease, which affects about 100,...
Sickle cell disease (SCD) is a group of genetic disorders in which an abnormal Hb molecule (Hb S) transforms RBCs into sickle-shaped cells, resulting in chronic anemia, vasoocclusive episodes, pain, and organ damage. Sickle cell trait, which is the heterozygous condition, is the only 1 of...
Although the Stroke Prevention Trial in Sickle Cell Anemia (STOP) demonstrated the efficacy of blood transfusions for primary stroke prevention in high-ris... J Heather,Fullerton,J Robert,... - 《Blood》 被引量: 227发表: 2004年 Stroke in children with sickle cell disease Children with sickle...
Sickle cell disease is a genetic blood disorder that can lead to anemia, body pain and organ damage. Learn more at Children's Health.
School of ScienceJimei UniversityBritish Medical AssociationBritish Medical JournalHuntsman RG, Lehmann H. Treatment of sickle-cell disease. Br J Haematol 1974; 28: 437-444.Charache S. Treatment of sickle-cell anemia. Annu Rev Med 1981; 32: 195-206....
Controlling the anemia Relieving symptoms Stem cell transplantationmay cure sickle cell disease. Bone marrow or stem cells from a family member or other donor who does not have sickle cell disease may be transplanted in a person with the disease. Such transplantation may be curative. ...
The most common and most severe form of SCD is the homozygous state known as Sickle Cell Anemia (SCA) due to inheritance of hemoglobin S (HbS) from each parent [1]. The inheritance of HbS in heterozygous state with a normal Hb is known as sickle cell trait which is not part of SCD ...
Sickle cell anemia; Children; Africa 1. Introduction Sickle cell disease (SCD) is a genetic blood disorder affecting red blood cells, with high morbidity and mortality rates. Sickle haemoglobin (HbS) is a structural variant of normal adult haemoglobin (HbA) (Chakravorty & Williams, 2015). SC...
Sickle cell anemia is an inherited form of anemia — a condition in which there aren’t enough healthy red blood cells to carry adequate oxygen throughout your body. Normally, your red blood cells are flexible and round, moving easily through your blood vessels. In sickle cell anemia, the ...