RBC transfusion in sickle cell anemia (HbSS): experience from the Jamaican Cohort Study. Transfusion 2001;41:596-601.Thame JR, Hambleton IR, Serjeant GR. Red cell transfusion in homozygous sickle cell disease: experience from the Jamaican Cohort Study. Transfusion 2001; 41 : 596-601....
Sickle cell anaemia is a View Solution Assertion:HbSHbSis homozygous condition of sickle cell anaemia. Reason: It occurs due to substitution of glutamic acid by valine at sixth position inβ-chain of haemoglobin. View Solution Exams IIT JEE ...
Sickle cell disease is any syndrome with a sickle mutation that alters normal beta globin: Determined by specific allelic pairings Autosomal recessive inheritance Homozygous genotype = HbSS ; causes sickle cell anemia Heterozygous condition = HbSA ; benign carrier condition called “ sickle cell tr...
Types of Sickle Cell Disease The most common types are: Hemoglobin SS (HbSS, also called sickle cell anemia) Hemoglobin SC (HbSC) HbS beta thalassemia (two types: HbSβ 0-thalassemia and HbSβ +-thalassemia) These types are rare: HbSD HbSE HbSOLiving...
and high-performance liquid chromatography — which identifies theabnormal hemoglobinthat differs from normal hemoglobin by charge. Additionally, these methods are able to differentiate homozygous SCD (HbSS,sickle cellanemia) from double heterozygous inheritance of the sickle gene and other abnormal hemoglobi...
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), a
Two-thirds of people with SCD produce only HbS as the adult form of hemoglobin, because they are either homozygous for the HbS mutation (HbSS) or compound heterozygous for the HbS and β0thalassemia muta- tions (HbSβ0thalassemia), and have sickle cell anemia (SCA) (8,9). The remaining...
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Buckalew, V. M. Jr & Someren, A. Renal manifestations of sickle cell disease.Arch. Intern. Med.133, 660–669 (1974). PubMedGoogle Scholar Alleyne, G. A. The kidney in sickle cell anemia.Kidney Int.7, 371–379 (1975). CASPubMedGoogle Scholar ...
Sickle cell anemia (SCA) is a disease caused by production of abnormal hemoglobin, which binds with other abnormal hemoglobin molecules within the red blood cell to cause rigid deformation of the cell. This deformation impairs the ability of the cell to pass through small vascular channels; slud...