diagnosiserythrocytesgenetic disordershaemoglobinhuman diseasessickle cell anaemiathalassaemiatransplant recipientsDIAGNOSIS OF SICKLE-CELL ANÆMIA AFTER BLOOD-TRANSFUSION. By - R.G. Hendricksedoi:10.1016/S0140-6736(58)90236-8HendrickseR.G.Elsevier Ltd.Lancet...
Sickle cell anaemia, diagnosisScreening programs for sickle cell disease, when effective, can reduce morbidity and mortality as a direct consequence of patient education and optimized clinical management. However, informed patient or parental consent is necessary prior to the screening process as a ...
Kan, Y. W., & Dozy, A. M. Antenatal diagnosis of sickle-cell anaemia by DNA analysis of amniotic-fluid cells.Lancet2,910–912 (1978a) ——. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: Relationship to sickle mutation.Proceedings of the National Academy of Sc...
1.1.3 What is sickle cell anaemia? It is the homozygous state which occurs when both genes are abnormal – S mutation (Hb SS). It is the most common and most severe form. Both copies of the hemoglobin beta gene have S mutation. All beta subunits are replaced by beta S. Fetal hemoglob...
摘要: ANTENATAL DIAGNOSIS OF SICKLE CELL ANAEMIA BY SENSITIVE DNA ASSAY. By - JudyC. Chang, MitchellS. Golbus, Yuet Wai Kan关键词: amniotic fluid anaemia diagnosis genetic disorders glutamic acid haemoglobin human diseases molecular genetics nucleotide sequences prenatal diagnosis ...
The acceptability of prenatal diagnosis (PND) of sickle cell anaemia (SCA) as a means of controlling sickle cell disorder in Nigeria was examined using a structured questionnaire. The respondents were comprised of 92 adult female patients with SCA, aged 15–20 (23 ± 6) years; 53 HbAS mother...
(βs/βs, -α/-α).Table IIIlists the unique features of this type of sickle cell anaemia.[57–60] Noteworthy is that hemoglobin A2 (Hb A2) is elevated in sickle cell anaemia with two α gene deletions, a finding that confuses this diagnosis with S-β-thalassemia that is typically ...
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferi- ority trial. Lancet 2016;387:661–70. 38. Ballas SK, ...
Sickle-cell anaemia was described first in 1910 and this was followed by the discovery of the symptomless sickle-cell trait present in about 9 per cent. of... S Charache - 《Annual Review of Medicine》 被引量: 314发表: 1981年 Confirmation of an association between the TNF(-308) promoter...
Among seven cases of sickle cell disease reported in detail, Professor Bauer and Dr. Fisher found five in whom the diagnosis had not even been suspected during life but was made at post-mortem. They emphasize the importance of recognizing that anaemia is not an obligatory sign of sickle cell...