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Nevertheless, even with lifetime exposure, the minimal risk imparted by a single genetic variant still requires a large sample size of several thousand to provide a robust definitive conclusion. MR analysis with large sample sizes provide for much greater sensitivity than can be expected from a ...
2.5. Sample Size, Randomization and Blinding Based on published data and using an expected change in WGTT of 20 h, standard deviation of 29.7 h [58] and setting α = 0.05 and β = 0.20, a sample size of 35 subjects per group was calculated. Subjects were randomly assigned into the ...