These results indicate that compound of formula (I) should be stored refrigerated for long term storage. EXAMPLE 2 The solubility of the compound of formula (I) was determined in a wide range of organic solvents. The solubility data is shown in Table 4 below. TABLE 4 Solvent Min solvent ...
Short-chain fatty acids show not only local effects on the colon epithelium, but after passage from the intestines to the bloodstream, they can also bind to fatty acid receptors - GPR41, GPR43, OLFR78, located in peripheral tissues [2]. In this way, SCFAs are able to regulate some physi...
Unlike red blood cells, which can be stored for forty-five (45) days, platelets can be stored for only five to seven days. The short storage term, or shelf-life, of the platelets severely limits the useful span for a platelet supply. A consequence of this short shelf-life is that plat...
Delivery of an agent often requires a carrier to get an active agent to target cells. Therapeutic effects in individuals are tied to those in compliance, and therefore oral delivery therapeutics tend to be more effective than injected therapeutics simply owing to better patient compliance with a do...
The term “in vivo half-life”, as used herein, means the time it takes for the concentration of a drug in the blood or the amount of a drug in vivo to be decreased to its original half. The calculation formula of in vivo half-life (shown as t1/2) is: t1/2=0.693/k, wherein...