A short sequence of amino acids including Lys-128 is required for the normal nuclear accumulation of wild-type and deleted forms of SV40 large T antigen. A cytoplasmic large T mutant that lacks sequences from around Lys-128 localizes to the nucleus if the missing sequence is attached to its...
Numerous in vitro studies have demonstrated that the toxicity was attributable to the nonionized forms of these acids, which exist more prominently at low pH (Baskett & Hentges, 1973; Bergeim, 1940; Hentges, 1967; Weiner & Draskoczy, 1961). These early studies also established the ...
MucosalImmunology | VOLUME 8 NUMBER 1 | JANUARY 2015 51 ARTICLES Figure 2 Antimicrobial activity of short and long forms of thymic stromal lymphopoietin (sf and lfTSLP) and the effect of sfTSLP on signal transducer and activator of transcription 5 (STAT5) phosphorylation of CD1c þ dendritic...
A common feature of SDRs is a propensity to form oligomeric structures and most SDRs are known to exist in dimer and tetramer forms (Jörnvall et al., 1995). While available three-dimensional structures suggest that many features, such as the Rossmann fold, are conserved among members of...
A case in point is ATG7, an E1-like enzyme, which forms a central element of two ubiquitin-like conjugation systems required for the lipidation of LC3/GABARAP3. In the first system, ATG7 binds and transfers ATG12 to the E2-like enzyme ATG10, which then transfers ATG12 to ATG5. ATG12-...
It was found that the CC derivatives of the D-forms of alanine (C_1), amino butyric acid(C_2), norvaline (C_3), and norleucine (C_4) bound to the dansyl-L-proline site much more strongly than their L-forms, whereas the interactions between both enantiomers of these amino acids ...
Vpu from human immunodeficiency virus type-1 (HIV-1) is an 81 amino acid type I integral membrane protein. Vpu forms ion conducting homooligomeric assemblies. To assess the energy landscape of an ion traversing the channel or pore single ion potentials of mean force (PMF) are reconstructed ...
5) All amino acids except tryptophan were found in free forms. Among them, taurine, glycine, alanine, glutamic acid and arginine were predominant. After acid-hydrolysis, the amount of the amino acids except taurine and acid-labile ones increased considerably (Table 3). Most of the combined ...
et al. The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N–L1–L2 domain protein. Nucleic Acids Res. 52, 2530–2545 (2024). Article PubMed PubMed Central Google Scholar Mayo-Munoz, D. et al. Type III CRISPR–Cas provides resistance against ...
The RNA containing expanded CGG repeats (rCGGexp) causes cell damage by interaction with complementary DNA, forming R-loop structures, sequestration of nuclear proteins involved in RNA metabolism and initiation of translation of polyglycine-containing protein (FMRpolyG), which forms nuclear insoluble ...