Bcl-X protein, which is related to Bcl-2, is present essentially in the nervous system and the immune system, under 2 different forms: Bcl-XL, like Bcl-2, is able to prevent apoptotic death of cultured lymphocytes; in contrast, Bcl-XS, which differs from the former one by a deletion ...
A short sequence of amino acids including Lys-128 is required for the normal nuclear accumulation of wild-type and deleted forms of SV40 large T antigen. A cytoplasmic large T mutant that lacks sequences from around Lys-128 localizes to the nucleus if the missing sequence is attached to its...
Yet there is very limited information about the formation of carbonaceous DBPs (C-DBPs) and nitrogenous DBPs (N-DBPs) from the chlorination of those AAs in combined forms which are more abundant than free AAs in source waters. In this study, we compared the differences on the formation of ...
MucosalImmunology | VOLUME 8 NUMBER 1 | JANUARY 2015 51 ARTICLES Figure 2 Antimicrobial activity of short and long forms of thymic stromal lymphopoietin (sf and lfTSLP) and the effect of sfTSLP on signal transducer and activator of transcription 5 (STAT5) phosphorylation of CD1c þ dendritic...
Programmed ribosomal frameshifting (PRF) is a fundamental gene expression event in many viruses, including SARS-CoV-2. It allows production of essential viral, structural and replicative enzymes that are encoded in an alternative reading frame. Despite t
Numerous in vitro studies have demonstrated that the toxicity was attributable to the nonionized forms of these acids, which exist more prominently at low pH (Baskett & Hentges, 1973; Bergeim, 1940; Hentges, 1967; Weiner & Draskoczy, 1961). These early studies also established the ...
(LF), which is 598 amino acids in length, an ‘intermediate’ form of 325 amino acids and two short forms of 352 (SF1a) and 264 (SF1b) amino acids. Different abundances and ratios of these forms have been associated with disease. For example, increased LF PRL receptor expression is ...
Theenzyme is a tetramer with a molecular weight of144 OOOl ] jwo major structural forms of the subunit,M and H chains, give rise to two different isoenzymes,M4 and H4, and three hybrids in higher vertebrates^2'3!.The isoenzymes differ in amino acid composition^4' aswell as in their ...
A case in point is ATG7, an E1-like enzyme, which forms a central element of two ubiquitin-like conjugation systems required for the lipidation of LC3/GABARAP3. In the first system, ATG7 binds and transfers ATG12 to the E2-like enzyme ATG10, which then transfers ATG12 to ATG5. ATG12-...
et al. The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N–L1–L2 domain protein. Nucleic Acids Res. 52, 2530–2545 (2024). Article PubMed PubMed Central Google Scholar Mayo-Munoz, D. et al. Type III CRISPR–Cas provides resistance against ...