Definition Chapters and Articles Related Terms Recommended Publications Featured Authors Chapters and Articles You might find these chapters and articles relevant to this topic. Animal Models of Human Disease Eric S. Goetzman, in Progress in Molecular Biology and Translational Science, 2011 A ...
(homozygous or heterozygous) for each locus.Chapter 6has an explanation of the workings of capillaryelectrophoresis.Figure 6.15shows a capillary electropherogram of a DNA sample. Since all 13 loci are detected during the same run, there is a large amount of data for analysis. Allelic ladders, ...
Potential disease genes were identified under an autosomal recessive and X-linked recessive models, identifying either homozygous variants in one gene, two changes in the same gene, or hemizy- gous changes on the X chromosome because both of the potential for a hemizygous change producing disease...
SVs can have a pronounced phenotypic impact—disrupting gene function and regulation or modifying gene dosage. Multiple studies have highlighted their role in functional changes across populations [1,10,11] and species [12]. Their importance in medicine and molecular biology has been highlighted by m...
of this is simply coverage of the SV, as for most SV callers, the reads that support the reference allele have little to no impact on the SV calling. The abundant homozygous SVs in these cell lines still span many sequence contexts and allow meaningful testing of SV callers. CHM1 and ...
manual adjustment as reported in polyploidy species [52], calculation of new cluster separation score in soybean [48] and other genotype calling software such as ALCHEMY in highly homozygous rice samples [60]). As manual inspection and definition of assay failure varies greatly among studies, ...
Because the sequence of a SEP is by definition short, this could lead to some peptides not being detected after enzymatic digestion; more SEPs could be detected by use of multiple proteases or multi-dimensional separation schemes.26,27 By checking the information of SEPs in the OpenProt data...
The definition of coronavirus is correlated to the presence of 20–40 nm-long Spike glycoprotein, which protrude from the viral envelope (Figure 2) [73]. Figure 2. Schematic diagram of the structure of SARS-CoV-2 and its Spike protein. The protein S is placed inward on the envelope to ...
In this manner, the identification of the Lewis blood group and the “secretor phenotype” of ABH glycans level could play a key role for the severe development of the disease [71,72]. 4. Spike Protein Interactions The definition of coronavirus is correlated to the presence of 20–40 nm-...