Given these properties, long-acting insulins are typically given once daily in combination with prandial rapid-acting or short-acting insulin. In the treatment of T1D, the exception to needing long-acting insulin is when using an insulin pump. Because pumps constantly infuse rapid-acting insulin ...
Insulins are categorized in the tables below according to their onset and duration of action: rapid-, short-, intermediate-, long-acting, and premixtures of rapid or short-acting insulin combined with intermediate-acting insulin.Description Onset2Peak2Duration2Lead author: Jill Allen...
Rapid and Short - A c t i n g Mealtime Insulin Prandial and Mean GlycemiaJohnson, Mead
A Direct Comparison of Insulin Aspart and Insulin Lispro in Patients With Type 1 Diabetes. OBJECTIVE — Both rapid-acting insulin analogs, insulin aspart and lispro, attenuate prandial glucose excursion compared with human soluble insulin. This t... Plank,Johannes,Wutte,... - 《Diabetes Care...
The study included patients with T1D or T2D treated with glargine U100 or insulin detemir (IDet) and a rapid-acting insulin analog who were switched from basal insulin to degludec once-daily (at bedtime) under conditions of routine clinical practice. Any concomitant oral antidiabetic drugs were...
The prolonged time-action profile of short-acting insulin analogs shown in this study could provide an explanation to why preprandial insulins have not had the expected benefits. In daily life, the delay in pharmacodynamic responses after short-acting analog injections may ha...
Acute kidney injury (AKI) represents a significant challenge to global public health problem and is associated with poor outcomes. There is still considerable debate about the effect of mean blood glucose (MBG) and coefficient of variation (CV) of blood glucose on the short-term mortality of AKI...
Apart from ACE2, TMPRSS2, and CD147, other recently identified factors involved in SARS-CoV-2 cell invasion may contribute to the impairment of spermatogenesis by acting as receptors (e.g., receptor tyrosine kinase [AXL], kringle containing transmembrane protein 1 [KREMEN1], and asparaginase ...
The action of Drp1 depends on another BH3-only pro-apoptotic acting as a second hit to permeabilize the outer membrane. On the other hand, under certain circumstances mitochondrial fission is not associated with death. For example, Bax, Bak doubly deficient cells Cell Death and Differentiation ...
They inter alia interact with DNA acting as regulatory factors. Oligopeptides imitate the extracellular matrix (the most important part of the stem cell niche), which influences the fate of the stem cell [336,337]. Short peptides play an important role in the transmissi...