Main result Compared with short-acting opioids, use of long-acting opioids was associated with increased risk for unintentional overdose overall, with the risk seeming to be highest in the first 14 days (Table). Conclusion In veterans with chronic noncancer pain, use of long-acting opioids was...
Many cancer patients experience chronic and breakthrough pain necessitating the use of both immediate release (IR) and extended release (ER) opioids. The common strategy in treating chronic cancer pain is using ER opioids with the addition of IR opioids for breakthrough pain. The National Comprehen...
A phase I clinical trial The drug investigated in these studies, Opra Kappa, also with another long-acting KOP-r antagonist, JDTic, was referred to as LY2456302 [(S)-3-fluoro-4-(4-((2 (3,5-di- suspended after 2 of the 6 subjects who received this methylphenyl)pyrrolidin-1-yl)...
In light of the recently released US Centers for Disease Control and Prevention guidelines on opioid use in chronic noncancer pain, there is a pressing need to better characterize the effectiveness of long- and short-acting opioids.Ghodke, AmeerBarquero, StephanieChelminski, Paul R.Ives, Timothy...
Long-acting opioids and short- acting opioids: appropriate use in chronic pain management. Pain Med. 2009;10 Suppl 2:S79-S88.Fine PG, Mahajan G, McPherson ML (2009) Long-acting opioids and short-acting opioids: appropriate use in chronic pain management. Pain Med. 10 Suppl 2: S79-88....
Short-Acting Opioids Are Associated with Comparable Analgesia to Long-Acting Opioids in Patients with Chronic Osteoarthritis with a Reduced Opioid Equivalence Dosing.doi:10.1093/pm/pnx245Ameer GhodkeStephanie BarqueroPaul R ChelminskiTimothy J Ives...
A comparison of long- and short-act- ing opioids for the treatment of chronic noncancer pain: tailoring therapy to meet patient needs. Mayo Clin Proc. 2009;84:602-612.Argoff CE, Silvershein DI. A comparison of long- and short-acting opioids for the treatment of chronic noncancer pain: ...
Pedersen L, Borchgrevink PC, Riphagen II, Fredheim OM. Long- or short-acting opioids for chronic non-malignant pain? A qualitative systematic review. Acta Anaesthesiol Scand 2014;58:390-401.Pedersen L, Borchgrevink PC, Riphagen II, Fredheim OM. Long- or short-acting opioids for chronic ...
Short-acting opioids provide equivalent analgesia to long-acting opioids in patients with chronic osteoarthritis pain with a substantially reduced opioid equivalent requirementChelminski, PGhodke, ABarquero, SPiper, M SIves, T
Daily use of longacting opioids vs. daily use of shortacting opioids increases the risk of hypogonadism in men, one of the first studies to evaluate this association, presented during the 2012 American Academy of Pain Medicine Annual Meeting, has found.MPR First Report...