Pedersen L, Borchgrevink PC, Riphagen II, Fredheim OM. Long- or short-acting opioids for chronic non-malignant pain? A qualitative systematic review. Acta Anaesthesiol Scand 2014;58:390-401.Pedersen L, Borchgre
A phase I clinical trial The drug investigated in these studies, Opra Kappa, also with another long-acting KOP-r antagonist, JDTic, was referred to as LY2456302 [(S)-3-fluoro-4-(4-((2 (3,5-di- suspended after 2 of the 6 subjects who received this methylphenyl)pyrrolidin-1-yl)...
美国食品药品监督管理局已批准非阿片类止痛药舒泽曲吉用于短期疼痛管理。舒泽曲吉是20多年来首个获得监管认可的通过全新机制起作用的止痛药物,且不会带来成瘾或嗜睡的风险。与阿片类药物不同,该药物不会在大脑中发挥作用,而是阻断周围神经系统中某些疼痛感受细胞中的钠通道。对于慢性疼痛——最迫切需要更安全、非阿片...
Short-acting opioids provide equivalent analgesia to long-acting opioids in patients with chronic osteoarthritis pain with a substantially reduced opioid equivalent requirementChelminski, PGhodke, ABarquero, SPiper, M SIves, T
Daily use of longacting opioids vs. daily use of shortacting opioids increases the risk of hypogonadism in men, one of the first studies to evaluate this association, presented during the 2012 American Academy of Pain Medicine Annual Meeting, has found.MPR First Report...
Intraoperative Use of Long-Acting vs Short-Acting Opioids in Patients Undergoing Colon Cancer Surgery in an Enhanced Recovery After Surgery (ERAS) Centredoi:10.1016/j.clnesp.2024.10.041Nathaniel R. TanVera Q. LimKwang Yeong HowClinical Nutrition ESPEN...
An opioid is any compound, regardless of the structure, which has the functional and pharmacological properties of an opiate. Endogenous opioids are natural ligands for opioid receptors found in animals. Synthetic compounds include hydrocodone; oxycodone; hydromorphone; heroin; antagonists such as ...
In light of the recently released US Centers for Disease Control and Prevention guidelines on opioid use in chronic noncancer pain, there is a pressing need to better characterize the effectiveness of long- and short-acting opioids.Ghodke, AmeerBarquero, StephanieChelminski, Paul R.Ives, Timothy...
A comparison of long- and short-act- ing opioids for the treatment of chronic noncancer pain: tailoring therapy to meet patient needs. Mayo Clin Proc. 2009;84:602-612.Argoff CE, Silvershein DI. A comparison of long- and short- acting opioids for the treatment of chronic noncancer pain:...
Main result Compared with short-acting opioids, use of long-acting opioids was associated with increased risk for unintentional overdose overall, with the risk seeming to be highest in the first 14 days (Table). Conclusion In veterans with chronic noncancer pain, use of long-acting opioids was...