SWING was a prospective, observational study conducted in nine European countries primarily to assess direct treatment costs when switching from short-acting human insulins to rapid-acting insulin analogues (H-A) or vice versa (A-H) in patients with type 2 diabetes. Data were collected at a ...
In general, all long-acting preparations have a steady effect and minimal peak. Given these properties, long-acting insulins are typically given once daily in combination with prandial rapid-acting or short-acting insulin. In the treatment of T1D, the exception to needing long-acting insulin is...
Rapid and Short - A c t i n g Mealtime Insulin Prandial and Mean GlycemiaJohnson, Mead
A Direct Comparison of Insulin Aspart and Insulin Lispro in Patients With Type 1 Diabetes. OBJECTIVE — Both rapid-acting insulin analogs, insulin aspart and lispro, attenuate prandial glucose excursion compared with human soluble insulin. This t... Plank,Johannes,Wutte,... - 《Diabetes Care...
Short- acting insulin analogs were originally designed to fit this premise by synchro- nizing plasma insulin increase and food absorption (1). They are indeed absorbed more quickly than regular human insulin. However, this was demonstrated in nor- mal-weight healthy subjects...
Acute kidney injury (AKI) represents a significant challenge to global public health problem and is associated with poor outcomes. There is still considerable debate about the effect of mean blood glucose (MBG) and coefficient of variation (CV) of blood glucose on the short-term mortality of AKI...
The study included patients with T1D or T2D treated with glargine U100 or insulin detemir (IDet) and a rapid-acting insulin analog who were switched from basal insulin to degludec once-daily (at bedtime) under conditions of routine clinical practice. Any concomitant oral antidiabetic drugs were...
This work focusing on the current state-of-the-art short peptide-based therapeutical developments is the first global review written by researchers from all continents, as a celebration of 100 years of peptide therapeutics since the commencement of insulin therapy in the 19...
SARS-CoV-2 causes acute hyperglycemia and insulin resistance in non-diabetic patients and exacerbates diabetes in pre-diabetic individuals [112,113,114], which is likely mediated by the increased expression of ACE2 in the exocrine glands and islets of the pancreas. SARS-CoV-2 infiltration with ...
The action of Drp1 depends on another BH3-only pro-apoptotic acting as a second hit to permeabilize the outer membrane. On the other hand, under certain circumstances mitochondrial fission is not associated with death. For example, Bax, Bak doubly deficient cells Cell Death and Differentiation ...