免疫组织化学目的探讨弥漫性大B细胞淋巴瘤(DLBCL)组织中音猬因子(Shh),平滑受体蛋白(Smo),神经胶质瘤相关癌基因同源蛋白1(Gli1)的表达及其临床意义.方法采用免疫组织化学SP法检测58例DLBCL组织标本及20例淋巴结反应性增生组织标本中Shh,Smo,Gli1的表达情况,分析Shh,Smo,Gli1表达与DLBCL临床病理特征的关系.结果Shh,...
and between membrane/cytoplasmic SMO and cytoplasmic GLI-1 in AOT (r= 0.667;p= 0.035) and OKC (r= 0.535;p= 0.015). The results of this study confirm the participation of the sonic hedgehog signaling pathway in the pathogenesis of the lesions studied. Overexpression of SHH in ABs and nucle...
Shh,Ptch1,Smo及Gli1 mRNA在胰腺癌组织中的相对表达量分别是0.652±0.036,0.604±0.063,0.493±0.011,0.512±0.052,在胰腺癌旁组织中为0.312±0.013,0.319±0.053,0.214±0.046,0.247±0.059(P0.05).与正常胰腺组织相比,胰腺癌组织中Shh,Ptch1,Smo及Gli1 mRNA表达量显著升高(P0.05),胰腺癌组织中Shh,Ptch1,Smo及...
图4 胰腺癌组织和癌旁组织Gli1 mRNA表达的电泳图.1-3: 胰腺癌组织; 4-6: 癌旁组织. 引文著录:依马木买买提江•阿布拉, 李东伟, 易超, 李海军. Hedgehog信号通路基因Shh、Ptch1、Smo及Gli1在胰腺癌中的表达及意义.世界华人消化杂志2015; 23(18): 2894-2900...
基因突变导致,形似刺猬,故名Hedgehog.在脊椎动物中至少发现三种同源基因:Sonic hedgehog(SHH),Indian hedgehog(IHH)和Desert hedgehog(DHH),分别编码三种相应的蛋白:SHH,IHH和DHH[6].每个基因的组成,主要由配体Hedgehog,跨膜蛋白受体Patched(Ptch1和Ptch2)和Smoothened(Smo)以及下游的转录因子Gli(Gli1,Gli2和Gli3)...
29常规体外培养,随机设定空白组和不同浓度(1、3、5 nmg/ml)白花蛇舌草乙醇提取物组,干预24 h,倒置显微镜观察细胞形态变化;MTT法测定不同浓度药物对HT-29细胞增殖的影响,并用5 mg/ml浓度干预1、3、6、12、24、48 h观察对HT-29细胞增殖的影响;RT-PCR检测药物作用后HT-29细胞Shh、Ptch、Smo和Gli-1 mRNA的...
显示Shh,Smo,Ptch1及Gli1染色主要位于子宫腺体及内膜周围.Shh在各组大鼠均无表达.Smo在刮宫后24h表达很弱,72h后表达逐渐增强.Ptch1在刮宫后24h为弱表达,72h后表达量明显上升.Gli1在刮宫后72h及7d表达量明显增加.实时定量PCR结果显示Shh mRNA在各组各时间点大鼠子宫均无表达.与正常组子宫内膜相比刮宫后24hSmo ...
Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis. Toxicol Lett 2014;225(2):318-24.Zhao LN, Yu YN, Deng CN: Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats ...
Effect of diosgenin on SHh, SMO and GLI1 gene expression during megakaryocytic differentiation in HEL and TF1a cell lines.Lamia, GhezaliBertrand, LiagreYouness, LimamiJeanLouis, BeneytoutDavid, Yannick Leger
PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic keratocysts. Int J Oral Maxillofac Surg 33:584-592.Ohki K, Kumamoto H, Ichinohasama R, Sato T, Takahashi N, Ooya K. PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic kerato...