( 1996 ). Gastrin induces tyrosine phosphorylation of Shc proteins and their association with the Grb2/Sos complex . FEBS Lett. , 378 , 74 – 78 .Seva C, Kowalski-Chauvel A, Blanchet JS, Vaysse N, Pradayrol L. Gastrin induces tyrosine phosphorylation of Shc proteins and their association...
The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants ...
(p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike ...
First, the Grb2/Sos complex can be recruited directly to activated receptors with ensuing Ras activation. Second, in Shc–/– cells, derived from knockout mouse embryos, Ras activation seems to proceed normally [8]. A possible unifying scenario derived from the finding that at low concentration...
还有研究说明[11],中等浓度H2O2刺激肾小管上皮细胞EGFR活化,使其与p46/p52Shc,Grb2和SOS形成复合体,激活下游ERK,促进细胞存活;而高浓度H2O2诱导p66ShcSer36磷酸化,与p46/p52Shc竞争结合Grb2,负调控EGFR/Ras/ERK途径,导致肾小管上皮细胞存活率降低。©...
背景资料Signaling adapter that couples activated growth factor receptors to signaling pathway.Isoform p46Shc and isoform p52Shc,once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic ...
Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in... S Tridandapani,T Kelley,D Cooney,... - 《Immunology Today》 被引量: 292发表: 1997年 Role of tissue angiotensin II in myocardial remo...
pathways.Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.Isoform p46Shc and isoform p52Shc,once phosphorylated,couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic ...
的RTK后,Grb2的另一个SH3结构域即可结合SOS(sonof sevenless)。SOS是一种Ras特异的鸟核苷酸交换因子,Ras 是一种鸟核苷酸结合蛋白,具有内源性GTP酶活性。SOS蛋 白招募Ras蛋白,SOS蛋白通过促进Ras蛋白进行GDP与 GTP的交换来激活或失活Ras:在 SOS 的作用下,Ras 的 GDP ...
(p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike ...