Objective: This study investigated the prospective associations of circulating levels of sex hormone-binding globulin (SHBG) levels with cardiometabolic biomarkers and risk of gestational diabetes (GDM) during pregnancy. It also...
In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation. The aim of the study was to examine the relationship between SHBG, total testosterone, total E2, and in...
Sex steroids, in particular low bioavailable estradiol and high sex hormone-binding globulin (SHBG), are associated with bone loss and high SHBG is associated with vertebral fractures in older men. We, therefore, hypothesized that low bioavailable estradiol and high SHBG would be associated with ...
In women, small amounts of testosterone are produced by the ovaries and the adrenal glands. Even slight increases in testosterone production can disrupt the balance of hormones and cause symptoms such as irregular or missed menstrual periods, infertility, acne, and excess facial and body hair (hir...
High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific DataMendelian randomization analysisFemaleFracturesBoneSex hormone-binding globulinTestosterone...
We had previously studied 135 adults +men and women. Adult FGF levels were lower than in children (iii : 18,34 4,44 pmol/ml, p< 0,051 and no sex difference was +found. Mean FGF value in blood cord of 8 neonates boys was lower than in I46 years children (B : 15,58 3,83 ...
The incidence of coronary artery disease is significantly higher in men than in women, at least until menopause. This gender difference could be explained by the action of sex steroids on the lipoprotein profile. In prepubertal children, high-density lipoprotein (HDL) cholesterol and triglyceride lev...
Barrett-Connor, Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo study. J. Bone Miner. Res. 12, 1833–1843 (1997) Article PubMed CAS Google Scholar A. Bjornerem, N. Emaus, G.K. Berntsen, R.M. Joakimsen, V. Fonnebo, T. Wilsgaard, P...
“SHBG typically circulates at higher concentrations in women than in men, due to the higher ratio of estrogens to androgens in women...” ...relationship to Breast Cancer “It has been reported that women with high levels of sex hormone binding globulin –which reduces the activity of th...
TNF-α and HOMA-IR levels were significantly higher, but SHBG levels were significantly lower among women who subsequently developed GDM compared with normal pregnant woman. TNF-α and SHBG levels in GDM were positively correlated with the level of HOMA-IR, but not in normal pregnant woman. ...