Plasma samples were pooled per time point, after which the concentration was determined in plasma by means of LC-MS. Pharmacokinetic parameters (AUC(0-6h), Cmax and Tmax) were derived from the obtained concentration versus time curves using the non-compartmental analysis module in Animals! or ...
LCMS: for C15H20N2O8 calculated 356.1. found 355.0 [M−H]− (negative). Compound 1 (2R,3R,4R,5R)-2-{[({[(2R,3R,4R,5R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxyt etrahydrofuran-3-yl]oxy}{[(4S,5S)-5...