Bottom: Alignment of receptor W0 and mutant sequences containing the target site. In the receptor sequence, the target sequence adjacent to the underlined PAM is indicated in red. The newly generated UGT71C4-KO-3 and UGT71C4-KO-5 mutants harbored a 1-bp T deletion and a 1-bp A ...
Blocking endocytosis with a dynamin dominant negative mutant prevents cell to cell transfer of pathology [64]. It is not clear if this is mediated by a selective uptake mechanism, e.g. a specific receptor that binds α-Syn, although α-Syn aggregates appear to have an affinity for heparan ...
Bottom: Alignment of receptor W0 and mutant sequences containing the target site. In the receptor sequence, the target sequence adjacent to the underlined PAM is indicated in red. The newly generated UGT71C4-KO-3 and UGT71C4-KO-5 mutants harbored a 1-bp T deletion and a 1-bp A ...