The article discusses research on the tubular shape of endoplasmic reticulum (ER). It references a study by Junjie Hu and Tom Rapoport published in the 2008 issue of "Science" which found that two proteins are sufficient to form tubules at the ER. In the study, the authors purified Yop1p...
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders Introduction ER stress and the UPR- The IRE1 axis: non-conventional splicing of XBP1 mRNA- The PERK axis: attenuation of translation- The ATF6 axis: regula... KM Doyle,D Kennedy,AM Gorman,... - 《Journal of Cell...
Harvard Medical School cell biologists have now cracked the code for part of the endoplasmic reticulum (ER), aprotein- and fat-making organelle that consists of stacked sheets in some parts and a complexnetworkof tubules in others. Producing the ER's tubular network is "surprisingly simple," r...
Thus, our results reveal a link between cation homeostasis and the control of cell shape, microtubule dynamics, and cytokinesis, and appoint Ca2+as a key ion in controlling these processes. 展开 关键词: Schizosaccharomyces pombe P-type ATPase Endoplasmic reticulum Calcium Microtubule ...
the effects were predominantly driven by sex hormones. Additionally, we found that microglial ultrastructure – particularly markers of cellular stress, such as mitochondrial elongation and dystrophy, endoplasmic reticulum (ER) and Golgi apparatus dilation, and extracellular digestion – was primarily influen...
Cell and organelle shape are driven by diverse genetic and environmental factors and thus accurate quantification of cellular morphology is essential to experimental cell biology. Autoencoders are a popular tool for unsupervised biological image analysis
5C). We performed GSVA analysis to investigate the biological functions of tumor cluster 3, which demonstrated significant activation of B cell mediated immunity, mesenchymal epithelial transition, cell–cell adhesion, protein exit from endoplasmic reticulum, etc. (Fig. 5D, Additional file 4: Table ...
Nuclear envelope tension can be measured using a membrane tension sensor targeted to the endoplasmic reticulum (ER) membrane (ER Flipper-TR) detected by fluorescence lifetime imaging (FLIM)36,37. Unfortunately, DCs failed to take up this sensor probe. We therefore turned to HeLa cells, which we...
Transformation转化 and storage存储 of energy in cell are the main function of _. E. mitochondria线粒体 F. microbodies微体细胞 G. endoplasmic reticulum内质网 Meiosis减速分裂 results in _ no change in chromosome number reduction in chromosome染色体 number doubling of chromosome number utotrophic自养型...
Gia Voeltz is using in vitro assays, cell biology, and electron microscopy to investigate how the endoplasmic reticulum (ER) acquires its tubular shape and... Sedwick,C. - 《Journal of Cell Biology》 被引量: 0发表: 2008年 Gia Voeltz: shaping ideas about ER shape. Interviewed by Caitlin Se...