SH3BP5-AS1N6-methyladenosinePancreatic cancerChemoresistanceWnt signaling pathwayEXPRESSIONCTBP1GEMCITABINEBackground Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently ...
SH3BP5-AS1在不同肝癌细胞系Huh 7,BEL-7405,SNU-387和Hep 3B中均不同程度高表达.siRNA沉默SH3BP5-AS1抑制Hep 3B细胞的增殖能力,促进细胞凋亡能力,影响细胞周期,G_(1)期细胞增多.肝癌组织中SH3BP5-AS1与TM6SF2表达负相关.结论 SH3BP5-AS1是一个重要的促癌非编码RNA,该研究为肝癌患者的肿瘤靶向治疗提供...
In addition, SH3BP5-AS1 promoted cellular glycolysis via miR-6838-5p sponging and PTPN4 activation. Lastly, by directly interacting to the promoter of SH3BP5-AS1, HIF-1伪 could control the transcription of the gene. Conclusions: Our research suggests that SH3BP5-AS1 controls miR-6838-5p/...
缺血性中风单核苷酸多态性中医证候同病异证目的研究旨在探讨中国汉族人群中lncRNA SH3BP5-AS1多态性rs11713836与缺血性中风(ischemic stroke,IS)遗传易感性及中医证候的关系.方法研究包括774例IS患者和793例对照组.采用Massarray SNP基因分型方法进行基因分型.采用《中风病中医辨证诊断标准》量表对IS患者进行中医证候...
Results: Six MRLNRs were significantly correlated to prognoses of LUAD patients, of which AL359220.1, SH3BP5-AS1 and ZF-AS1 were further used to establish a metastasis-related risk scoring model (MRRS) due to the close associations with overall survival of LUAD patients. According to the ...