探究6-OHDA诱导的SD大鼠模型中,GLP-1/GIP双受体杂合肽DA-CH5相对于GLP-1受体激动剂Exendin-4是否更具有优势.方法:1.立体定位手术及实验分组:将大鼠麻醉固定于立体定位仪上,根据大鼠脑立体定位图谱定位,用颅骨钻在大鼠颅骨相应位置打眼,将5μL 6-OHDA溶液(2mg/m L)经微量注射器注入右侧内侧前脑侧束中(MBF)....
Using site-directed mutagenesis and gene recombination techniques, we generated a mutated recombinant human glucagon-like peptide-1 (mGLP-1) which has longer half-life as compared with native GLP-1. This present work aims to examine whether mGLP-1 attenuates Aβ1–42-mediated cytotoxicity in SH...