Heart failureSGLT2 inhibitorsSGLT2 inhibitors (SGLT2i) are new drugs for patients with heart failure (HF) irrespective of diabetes. However, the mechanisms of SGLT2i in HF remain elusive. This article discusses the current clinical evidence for using SGLT2i in different types of heart failure ...
Patients with heart failure and preserved ejection fraction (HFpEF) have a high burden of symptoms and functional limitations, and have a poor quality of life. By targeting cardiometabolic abmormalities, sodium glucose cotransporter 2 (SGLT2) inhibitors may improve these impairments. In this multic...
[4]O'Meara E, McDonald M,Chan M,et al.CCS/CHFS Heart Failure Guidelines: Clinical Trial Update on Functional Mitral Regurgitation, SGLT2 Inhibitors,ARNl in HFpEF, and Tafamidis in Amyloidosis[]]Can J Cardiol,2020,36(2):159-169. [5]廖梦阳...
Investigators found that sodium-glucose contrasporter-2 (SGLT2) inhibitors demonstrated effectiveness for the primary and secondary prevention of heart failure (HF) across a broad range of care settings and patient populations. irissca - stock.adobe.com The results of a review, published in Cureus...
SGLT-2 inhibitors in heart failure: a new therapeutic avenueDapagliflozin, a sodium-glucose co-transporter-2 inhibitor, reduced the risk of cardiovascular death or heart failure events in 4,744 patients with chronic heart failure with reduced ejection fraction....
SGLT2 InhibitorsRichard K. Cheng MD, MScDeidre M. Mooney MD, MPHChristopher V. Chien MDKevin S. Shah MDAmanda Vest MBBS, MPHJohn L. Jefferies MD, MPHJournal of the American College of Cardiology
Overall, treatment with SGLT2 inhibitors reduces BP in T2DM patients without a compensatory increase in the heart rate (HR). Based on this observation, it has been postulated that the moderate diuretic effect of SGLT2 inhibitors does not activate neurohumoral factors and thus is beneficial for HF...
The Research Into the Effect of SGLT2 Inhibition on Left Ventricular Remodeling in Patients With Heart Failure and Diabetes Mellitus (REFORM) trial was the first to try to determine the mechanistic effect of SGLT2-inhibitors specifically in the HF population. At 1 year, no significant difference ...
Both heart failure and diuretic or SGLT2 inhibitor use increase fall risk in older adults. Diuretics and SGLT2 inhibitors not only have various fall-related adverse effects, which partly overlap (e.g. tendency to cause hypotension), but also differ: compared to SGLT2is, diuretics display more...
Sodium–glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of kidney disease progression and hospitalization for heart failure, both in patients with CKD and in patients with heart failure. The beneficial effects of SGLT2 inhibitors on kidney function and heart failure are consistent across...