本文由“天纳”临床学术信息人工智能系统自动翻译 In this video, Javed Butler, MD, introduces the series on the use of SGLT2 inhibitors in heart failure. He discusses the epidemiology of heart failure and the effects of...
Together, these promising features place them as a potential novel treatment for heart failure.doi:10.1007/s11897-017-0345-9Verbrugge, Frederik H.Martens, PieterMullens, WilfriedCurrent Heart Failure ReportsVerbrugge FH, Martens P, Mullens W: SGLT-2 Inhibitors in heart failure: Implications for the...
[8] Zannad F, Ferreira JP, Pocock SJ, Anker SD, Butler J, Filippatos G, etal. SGLT2 inhibitors in patients with heart failure with reduced ejectionfraction: a meta-analysis of theEMPEROR-Reduced and DAPA-HF trials. Lancet. 20...
该Meta分析包含5项相关研究（EMPEROR- PRESERVED、VERTIS-CV、DECLARE-TIMI 58、SOLOIST-WHF、SCORED）、9726例舒张性心衰患者，其中5046例接受SGLT2i治疗，4680例应用安慰剂。来源：[1]Sodium glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction: a systematic review and meta-ana...
[10]. Velliou M, Polyzogopoulou E, Ventoulis I, Parissis J. Clinical pharmacology of SGLT-2 inhibitors in heart failure. Expert Rev Clin Pharmacol. 2023 Feb;16(2):149-160. [11]. Hallow KM, Helmlinger G, Greasley PJ, McMurray JJV, Boulton DW. Why do SGLT2 inhibitors reduce heart...
[1]Milton Packer. Six lessons learned from the use of SGLT2 inhibitors in patients with heart failure. Nature Reviews Cardiology, 2022, 19: 499–500. [2]江耀辉,王喆,郑汝杰,等.达格列净对冠心病合并2型糖尿病患者临床结局的影响.中国循环杂志, 2022, 37: 250-255. DOI: 10.3969/j.issn.1000-361...
Dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, reduced the risk of cardiovascular death or heart failure events in 4,744 patients with chronic heart failure with reduced ejection fraction.doi:10.1038/s41591-019-0647-4Muthiah Vaduganathan...
Large traditional clinical trials suggest that sodium-glucose co-transporter 2 inhibitors improve symptoms in patients with heart failure and reduced ejection fraction (HFrEF) and in patients with heart failure and preserved ejection fraction (HFpEF). In the midst of the Coronavirus Disease 2019 pandemi...
Both heart failure and diuretic or SGLT2 inhibitor use increase fall risk in older adults. Diuretics and SGLT2 inhibitors not only have various fall-related adverse effects, which partly overlap (e.g. tendency to cause hypotension), but also differ: compared to SGLT2is, diuretics display more...
The results of a review, published in Cureus, show that the medications reduced the risk of HF. Investigators found that sodium-glucose contrasporter-2 (SGLT2) inhibitors demonstrated effectiveness for the primary and secondary prevention of heart failure (HF) across a broad range of care ...