[4]O'Meara E, McDonald M,Chan M,et al.CCS/CHFS Heart Failure Guidelines: Clinical Trial Update on Functional Mitral Regurgitation, SGLT2 Inhibitors,ARNl in HFpEF, and Tafamidis in Amyloidosis[]]Can J Cardiol,2020,36(2):159-169. [5]廖梦阳...
Heart failureSGLT2 inhibitorsSGLT2 inhibitors (SGLT2i) are new drugs for patients with heart failure (HF) irrespective of diabetes. However, the mechanisms of SGLT2i in HF remain elusive. This article discusses the current clinical evidence for using SGLT2i in different types of heart failure ...
现有证据表明,SGLT2抑制剂降低血清尿酸盐的幅度可能在1.8mg/dl左右【Yokose C et al. Serum urate change among gout patients initiating sodium-glucose cotransporter type 2 inhibitors (SGLT2i) vs. sulfonylureas: a comparative effect...
SGLT-2 Inhibitors in HeartFailureSGLT-2 inhibitorsdiureticsheart failureoutcomesvolume[Display omitted]doi:10.1016/j.jacc.2021.02.005Mikhail N. KosiborodMuthiah VaduganathanJournal of the American College of Cardiology
Patients with heart failure and preserved ejection fraction (HFpEF) have a high burden of symptoms and functional limitations, and have a poor quality of life. By targeting cardiometabolic abmormalities, sodium glucose cotransporter 2 (SGLT2) inhibitors may improve these impairments. In this multic...
Investigators found that sodium-glucose contrasporter-2 (SGLT2) inhibitors demonstrated effectiveness for the primary and secondary prevention of heart failure (HF) across a broad range of care settings and patient populations. irissca - stock.adobe.com The results of a review, published in Cureus...
1.World Health Organization Model List of Essential Medicines 22nd List (2021) 2.Christopher S. Wilcox. Antihypertensive and Renal Mechanisms of SGLT2 (Sodium-Glucose Linked Transporter 2) Inhibitors. Hypertension. 2020 Mar 2: 1-8. 3.王建平,朱巧林.钠-葡萄糖协同转运蛋白2抑制剂与糖尿病心血管并发...
Both heart failure and diuretic or SGLT2 inhibitor use increase fall risk in older adults. Diuretics and SGLT2 inhibitors not only have various fall-related adverse effects, which partly overlap (e.g. tendency to cause hypotension), but also differ: compared to SGLT2is, diuretics display more...
The Research Into the Effect of SGLT2 Inhibition on Left Ventricular Remodeling in Patients With Heart Failure and Diabetes Mellitus (REFORM) trial was the first to try to determine the mechanistic effect of SGLT2-inhibitors specifically in the HF population. At 1 year, no significant difference ...
Heart failure hospitalizations are due to congestion in 90% of the cases. SGLT-2 inhibitors reduce the rate of decline in renal function among diabetic patients.33 This could be relevant in decreasing HF hospitalizations. By lowering blood pressure, increasing aortic compliance and improving ventricula...