SGLT-2 Inhibitors for Heart Failure — Including Heart Failure with Preserved Ejection Fraction SGLT-2抑制剂治疗心力衰竭,包括射血分数保留的心力衰竭 评论作者:Daniel D. Dressler, MD, MSc, MHM, FACP 一项荟萃分析显示,此类药物对很大范围的射...
Heart failureRandomized controlled trialsDapagliflozin, a sodium-glucose co-transporter-2 inhibitor, reduced the risk of cardiovascular death or heart failure events in 4,744 patients with chronic heart failure with reduced ejection fraction.doi:10.1038/s41591-019-0647-4Muthiah Vaduganathan...
[5]SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials. Lancet, August 27, 2022 [6]Dapagliflozin for heart failure according to body mass index: the DELIVER trial. ...
SGLT2 Inhibitors to Treat Heart Failure Activity Do It Better: Raising the Bar in Heart Failure Care With Practical Strategies for Treatment With SGLT2 Inhibitors Released:March 14, 2025 Expiration:March 13, 2026 Javed Butler, MD, MPH, MBA ...
SGLT2 InhibitorsRichard K. Cheng MD, MScDeidre M. Mooney MD, MPHChristopher V. Chien MDKevin S. Shah MDAmanda Vest MBBS, MPHJohn L. Jefferies MD, MPHJournal of the American College of Cardiology
[1] M. Packer, et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. Presented at 2020 ESC. [2] Zelniker TA, Wiviott SD, Raz I, et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review...
Elderly patients with HF with reduced ejection fraction and renal failure: are SGLT2i a good option? AHA 2024. [7]. Tess Calcagno, et al. Impact of SGLT2 Inhibitors on Cardiovascular Outcomes Following Acute Myocardial Infarction with Heart Failure with Preserved Ejection Fraction: A Propensity-...
[8] Packer M.(2020). Cardioprotective effects of Sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (Sodium-Glucose Cotransporter 2) inhibitors, Circ Heart Fail, 13(9), e007197. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007197 [9] ...
EMPULSE is distinct from previous trials with SGLT2 inhibitors for several reasons. In particular, patients in EMPULSE were randomized early in the course of hospitalization for acute heart failure, at a median of 3 days after hospital admission. In the Effect of Sotagliflozin on Cardiovascular...
该Meta分析包含5项相关研究（EMPEROR- PRESERVED、VERTIS-CV、DECLARE-TIMI 58、SOLOIST-WHF、SCORED）、9726例舒张性心衰患者，其中5046例接受SGLT2i治疗，4680例应用安慰剂。来源：[1]Sodium glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction: a systematic review and meta-...