Introduction: The SGLT-2 inhibitors (SGLT-2i) are a newer anti-diabetic drugs. Their use has tremendously increased due to their favorable profile but they are also the focus of attention because of their side effect of euglycemic diabetic ketoacidosis (euDKA), which is challenging to diagnose...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors used for the treatment oftype 2 diabetes, and forheart failure, are associated with a nearly threefold increased risk fordiabetic ketoacidosis (DKA), according to a newlarge database analysis. The findings, which include data on the use of three...
Euglycemic diabetic ketoacidosis (EuDKA) secondary to Sodium-glucose co-transporter-2 inhibitors (SGLT2i) in type 2 diabetes mellitus (T2D) is a rare but increasingly reported phenomenon. Not much is known about the burden of EuDKA in patients on SGLT2i or the associated factors. This retrosp...
酮症酸中毒(DKA):恩格列净相关的DKA常常是正常血糖性DKA,大多发生于胰岛素缺乏的糖尿病病人,诱因多为手术、过度运动、心肌梗死、极低碳水化合物摄入等应激事件。 因此,使用本品期间可采取:避免胰岛素剂量不足或中断使用,在择期手术或侵入性手术前、严重急性疾病或...
Keywords:SGLT2inhibitors?Euglycemicdiabeticketoacidosis 0 引言 钠- 葡萄糖协同转运蛋白 2 ( Sodium~glucosecotransporter2?SGLT2) 抑制剂是一种新型的口服 降糖药物?临床上用于糖尿病患者的治疗?在减轻 体重和降低低血糖的发生率方面有较好的效果? 欧盟和美国批准上市的 SGLT2 抑制剂包括坎格 列净 ( Canagliflozin)...
然而,SGLT2i的使用与围术期酮症酸中毒(DKA)的风险增加有关,尤其是正常血糖水平下的酮症酸中毒(血糖浓度<11.0mmol/L)。这种酮症酸中毒的发生机制是由于SGLT2i导致的胰岛素/胰高血糖素比例失衡,使得脂肪分解加速,酮体生成增加。在围术期,由于手术应激等因素导致的儿茶酚胺等反调节激素分泌增加,进一步加剧了酮症的发生...
Both heart failure and diuretic or SGLT2 inhibitor use increase fall risk in older adults. Diuretics and SGLT2 inhibitors not only have various fall-related adverse effects, which partly overlap (e.g. tendency to cause hypotension), but also differ: compared to SGLT2is, diuretics display more...
然而,SGLT2i的使用与围术期酮症酸中毒(DKA)的风险增加有关,尤其是正常血糖水平下的酮症酸中毒(血糖浓度<11.0mmol/L)。这种酮症酸中毒的发生机制是由于SGLT2i导致的胰岛素/胰高血糖素比例失衡,使得脂肪分解加速,酮体生成增加。在围...
然而,SGLT2i的使用与围术期酮症酸中毒(DKA)的风险增加有关,尤其是正常血糖水平下的酮症酸中毒(血糖浓度<11.0mmol/L)。这种酮症酸中毒的发生机制是由于SGLT2i导致的胰岛素/胰高血糖素比例失衡,使得脂肪分解加速,酮体生成增加。在围术期,由于手术应激等因素导致的儿茶酚胺等反调节激素分泌增加,进一步加剧了酮症的发生...
In DAPA-CKD, no cases of DKA were reported with dapagliflozin treatment; however, all patients should receive counseling regarding “sick day” medication management upon SGLT2 inhibitor prescription. SGLT2 Inhibitors in Heart Failure Subsequent to the consistent benefits in heart failure hospitalization...