How Do SGLT-2 Inhibitors Work to Prevent Heart Failure?heart failuremediation analysesSGLT-2 inhibitorstrialsdoi:10.1016/j.jchf.2019.11.009Muthiah VaduganathanBrian L. ClaggettScott D. SolomonJACC: Heart Failure
SGLT-2抑制剂和GLP-1受体激动剂的联合使用_替代终点和硬终点的潜在好处.pdf,1879 Send Orders for Reprints to reprints@benthamscience.ae Current Pharmaceutical Design, 2018, 24, 1879-1886 REVIEW ARTICLE Combination of SGLT-2 Inhibitors and GLP-1 Receptor Agoni
SGLT2 inhibitors restore cellular homeostasis through three complementary mechanisms: they might bind directly to nutrient-deprivation and nutrient-surplus sensors to promote their cytoprotective actions; they can increase the synthesis of ATP by promoting mitochondrial health (mediated by increasing autophagic...
but it can also be the consequence of it [3]. This underscores the importance of optimal diabetes control in patients with HF. Although there is a multitude of efficacious medications for T2DM, they do not appear to reduce the risk of cardiovascular (CV) outcomes ...
Individuals were included if they had initiated one or more of the following four second- line glucose-lowering medications: SGLT2is, GLP1-RAs, dipeptidyl peptidase-4 inhibitors (DPP4is) or sulfonylureas (SUs). Treatment initiation was defined as a filled prescrip- tion for a study medication ...
(Fig.3). They have a beneficial effect on systolic blood pressure, although the reduction is only modest (2–6 mmHg) and insufficient to explain by itself the overall effects on CV mortality [119]. GLP-1Ra also lower total and LDL cholesterol and triglycerides [125,131]. However, it ...
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They may include the contribution of congestion control, the improvement in cardio-metabolic efficiency and the reduction in ventricular remodeling, among others. DAPA-HF and EMPEROR-Reduced trials provided evidence for the addition of dapagliflozin or empagliflozin to the present gold standard neuro...
Discussion In this work, we observed that Empa treatment effec- tively alleviates the renal pathological changes caused by T2DM; simultaneously, we characterized the specific feature of metabolic reprogramming that occurs in kid- ney and serum in the mice with DKD via multi-omics analysis and ...
reporting system Benedetta Maria Bonora1, Emanuel Raschi2, Angelo Avogaro1 and Gian Paolo Fadini1* Abstract Background: Sodium glucose cotransporter-2 inhibitors (SGLT2i) reduce the risk of heart failure and new data show they can prevent atrial fibrillation (AF)....