[7] Packer M.(2020). SGLT2 Inhibitors produce cardiorenal benefits by promoting adaptive cellular reprogramming to induce a state of fasting mimicry: A paradigm shift in understanding their mechanism of action, Diabetes Care, 43(3), 508–511. https://doi.org/10.2337/dci19-0074 [8] Packer ...
[1]ESC-HFA 2024 官网. [2]Brendon L. Neuen, Brian L. Claggett, Vlado Perkovic, et al. Timing of Cardio-Kidney Protection With SGLT2 Inhibitors: Insights From Four Large-Scale Placebo-Controlled Outcome Trials. Circu...
随后发现钠-葡萄糖共转运蛋白2抑制剂(sodium-glucose cotransporter 2 inhibitors, SGLT2i),如empagliflozin缓解了ALDH2*2相关的EC功能障碍。 图1. ALDH2*2与冠状动脉疾病(CAD)密切相关,并诱导内皮功能障碍(图源自 Science Translational Medicine ) 通过对ALDH2*2敲入小鼠的研究进一步证明,empagliflozin可在体内减弱ALD...
16. Palmer SC, Tendal B, Mustafa RA, et al. Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis o...
参考资料:1.心脏病学泰斗点评:SGLT2抑制剂——21世纪的他汀2.XieLingli,XiaWenfang.CharacteristicsandmolecularmechanismsthroughwhichSGLT2inhibitorsimprovemetabolicdiseases:Amechanismreview,(2022),https://doi.org/10.1016/j.lfs.2022.1205433.朱超,邵华,詹莹,厉伟兰,柳亚敏.钠-葡萄糖2型共转运蛋白抑制剂的降糖外作用...
该项研究结果表明SGLT2抑制剂可能在狼疮性肾炎中发挥积极地保护作用,为探索SGLT2抑制剂在非免疫抑制疗法中改善LN肾损伤提供了更多的线索。 主要发现 近日,Annals of The Rheumatic Diseases期刊在线发表了来自郑州大学第一附属医院肾脏病医院齐媛媛博士团队的题为“SGLT2 Inhibitors Alleviated Podocyte Damage in Lupus Ne...
2.XieLingli,XiaWenfang.CharacteristicsandmolecularmechanismsthroughwhichSGLT2inhibitorsimprovemetabolicdiseases:Amechanismreview,(2022),https://doi.org/10.1016/j.lfs.2022.120543 3.朱超,邵华,詹莹,厉伟兰,柳亚敏.钠-葡萄糖2型共转运蛋白抑制剂的降糖外作用[C]//.2014年中国药学大会暨第十四届中国药师周论文集....
Rieg T, Vallon V. Development of SGLT1 and SGLT2 inhibitors.Diabetologia. 2018;61(10):2079-2086. doi:10.1007/s00125-018-4654-7 Benedict SL, Mahoney OM, McKee TS, Bergman PJ. Evaluation of bexagliflozin in cats with poorly regulated diabetes mellitus.Can J Vet Res. 2022;86(1):52-58...
1. Tsimihodimos V, et al. Effects of sodium-glucose co-transporter 2 inhibitors on metabolism: unanswered questions and controversies. Expert Opin Drug Metab Toxicol. 2017 ;13:399-408. 2. Seufert J. SGLT2 inhibitors - an insulin-independenttherapeuticapproach for treatment of type 2 diabetes:...