环境应激增加其表达，SGK 在促进细胞生存、增殖和分化中起作用 (5)。特征: A synthetic peptide corresponding to residues of human SGK was used as an immunogen.推荐稀释度 :WB: 1:500 IHC: 1:50 Flow Cytometry: 1:30 IP: 1:50 A. Western blot analysis of anti-SGK RabMAb (cat. #...
Related to innate immunity, SGK1 negatively regulates the TLR4/NF-κB response in mice,32 promotes macrophage polarization to an M1 phenotype,33 and controls macrophage migration in vascular inflammation.34 SGK3 was shown to regulate Ca2+-mediated dendritic migration in response to lipopolysaccharides (...
The activation of 'de novo' ceramide synthesis leads to ceramide-induced apoptosis. Therefore, we also investigated whether inhibition of this process protects cells from ceramide-induced apoptosis. HEK-293 were treated with or without Fumonisin B1 (FB1), an inhibitor of ceramide synthase, and ...