Fold change of mRNA expression of various genes in the NO-sGC-PDE signaling pathway in 22-week old mdx/mTRG2 versus wild type C57BL6/J mice in the quadriceps. All values are expressed as mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001; *** p < 0.0001; ns, not sign...
(soluble guanylate cyclase). It was observed that important components of the NO-sGC-PDE like the NO producing eNOS and iNOS, the beta-1 subunit of the NO-receptor sGC as the cGMP downstream target PRKG2 were downregulated in the quadriceps of 22-week-old adult mdx/mTRG2mice compared to...