Conclusion: AAV-9 virus transfected sfrp1 can reduce cardiomyocyte apoptosis and improve cardiac function of rats with heart failure by targeting to inhibit wnt signaling pathway and myocardial collagen synthesis.项羽汪佩王军奎马彦鹏潘硕Progress in Modern Biomedicine...
Objective: To investigate the effect and molecular mechanism of adeno associated virus (AAV-9) transfection of soluble frizzled related protein 1 (Sfrp1) on wnt signaling pathway in rats with heart failure. Methods: Forty five healthy male SD rats were randomly divided into Matched group, model ...
分泌型卷曲相关蛋白1(SFRP1)重组蛋白 分泌型卷曲相关蛋白1是近来发现的新的抑癌基因, 是Wnt信号通道的拮抗通路蛋白,SFRP1能够阻断某些发生在癌症初期与之相关的细胞生长基因的信号通路。 详情介绍 Recombinant Secreted Frizzled Related Protein 1 (SFRP1) 分泌型卷曲相关蛋白1(SFRP1)重组蛋白 [ PROPERTIES ] Sou...
Wnt信号通路的异常激活与肿瘤的发生密切相关,T细胞因子4(Tcf4)和β连环蛋白(β-catenin)是该通路中重要的信号传递因子。本文应用免疫组织化学染色检测97例结直肠癌组织和40例正常黏膜组织中Tcf4、β-catenin和Wnt信号通路抑制因子分泌型卷曲相关蛋白1(SFRP1)的表达关系,探讨
Canonical Wnt/β-catenin signaling is one of the fundamental signaling pathways that is required for embryogenesis and maintenance of the adult body. Development of conditional alleles of β-catenin in the form of constitutively-active and loss-of-function mutations, as well as availability of tissue...
Colorectal tumorigenesis is ascribed to the activity of Wnt signaling pathway in a ligand-independent manner mainly through APC and CTNNB1 gene mutations and in a ligand-dependent manner through low ...
SFRP1 is a modulator of normal and malignant hematopoiesis and cell proliferation. Gene polymorphisms, aberrations and methylation of SFRP1 is a feature in bladder cancers resulting in excessive activation of Wnt pathway. Sequence【序列】 Synthetic peptide located within the following region: HQLDNL...
SFRPs act as soluble modulators of Wnt signaling. SFRP1 and SFRP5 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP1 is expressed in several human tissues, with the highest levels in heart. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation, morphology, and migration. Aberrant activation of the Wnt/β-catenin signaling pathway leads to the development of seve
中图分类号盈盟UDC610硕士学位论文学校代码!Q§圣三密级公珏牙周炎基础治疗前后龈沟液中SFRPl总量的变化Effectofperiodontalinit..