In order to perform a complete structural analysis of all possible DBHS dimers, we have solved the crystal structure of the missing DBHS heterodimer SFPQ-NONO at 3.0 resolution. We identify subtle changes in amino acid composition and local secondary structure of the NOPS region orientation that ...
NONO and SFPQ cover multiple biological functions that include transcriptional regulation, the formation of subnuclear structures such as paraspeckles, but also DNA damage repair, gene expression, cell cycle control, and circadian rhythm43,44. In this study, we exclusively focus on the role of NONO...
2011. Chromatin remodeling as a mechanism for circadian prolactin transcription: rhythmic NONO and SFPQ recruit- ment to HLTF. FASEB J. 25:2740 -2756.Guillaumond F., Boyer B., Becquet D., Guillen S., Kuhn L., Garin J., Belghazi M., Bosler O., Franc J.L., François-Bellan A.M...
Here, we tried to briefly review the main cellular functions of NEAT1 RNA and SFPQ and NONO proteins. The goal of this review was also to summarize and, if possible, systematize the existing data on their role in the HIV-1 life cycle....
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. Nucleic Acids Res. 2016; 44:3989-4004.Knott GJ, Bond CS, Fox AH. The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. Nucleic Acids Res. 2016;44(9):3989-4004. doi:10.1093/nar/gkw271....
NPPA-AS1 deletion promoted the binding of SFPQ-NONO heteromer, decreased DNA damage, and activated cardiomyocyte cell cycle re-entry. Together, loss of NPPA-AS1 promoted cardiomyocyte proliferation by stabilizing SFPQ-NONO heteromer-induced DNA repair and exerted a therapeutic effect against MI in ...
Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle 2010;9:1568-76.Salton M, Lerenthal Y, Wang SY, Chen DJ, Shiloh Y. Involvement of matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle 2010 ; 9:1568 - 1576; PMID: 20421735 ; http://dx.doi....
(2010) Involvement of matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle 9.Salton, M., Lerenthal, Y., Wang, S.Y., Chen, D.J., and Shiloh, Y. (2010). Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle 9, 1568-1576....
Downregulation of the long noncoding RNA in NHEJ pathway 1 (LINP1) by siRNA also blocked IGFBP-3 interaction with NONO-SFPQ. These findings suggest a PARP-dependent role for NONO and SFPQ in IGFBP-3-dependent DSB repair and the involvement of LINP1 in the complex formation. We propose ...
Lin, Mike Z.Phillips, LeoMartin, Janet L.Baxter, Robert C.SpringerCellular and Molecular Life Sciences CMLSde Silva, Hasanthi C.,Lin,etc.IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer[J].2019,76(10)....