该文揭示了SFMBT1是VHL的新底物,VHL的失活可导致SFMBT1的累积从而促进肾癌发生。 羟基化的HIF 与其它VHL的底物相互竞争VHL的结合位点。羟基化的HIF会抑制其它底物和VHL结合,而未羟基化的HIF则不能。据此,研究人员设置了巧妙的竞争筛选...
Genome-wide screening identifies SFMBT1 as an oncogenic driver in cancer with VHL loss[J]. Mol Cell, 2020, 77(6): 1294-1306.e5. JIANG Z J, SONG Q C, ZENG R, et al. MicroRNA-218 inhibits EMT, migration and...